Immunology

Question 1

What is primary lymphoid tissue?

Answer 1

Where stem cells differentiate into either T cells (thymus) or B cells (bone marrow).

Question 2

What is secondary lymphoid tissue?

Answer 2

Where mature T/B cells go to encounter antigens.

Question 3

Where is secondary lymphoid tissue in the body?

Answer 3

Lymph nodes
Spleen
MALT (mucosal-associated lymphoid tissue) and other locations in the body with excess lymphatic accumulations

Question 4

What three activities take place in the thymus?

Answer 4

1. Differentiation of thymocytes into T cells: early thymocytes express antigen receptors
2. Self/non-self discrimination
3. Elimination of self-reacting thymocytes

Question 5

What is involved in differentiation of thymocytes?

Answer 5

1. Cell-to-cell contact with cortical epithelial cells and dendritic cells
2. Thymic hormones
3. Cytokines