Induction Agent: Propofol

Question 1

What is the generic name of the drug commonly known as Diprivan?

Answer 1

Propofol

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Question 2

Which of the following are NOT uses of Propofol?

A) IV induction of anesthesia
B) Maintenance of anesthesia with TIVA
C) Long-term sedation in elderly patients
D) Management of PONV

Answer 2

C) Long-term sedation in elderly patients

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Question 3

What is the standard concentration of Propofol used for anesthesia?

Answer 3

10 mg/cc

(20cc vial standard). 1% lipid solution

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Question 4

PP: The typical induction dose of Propofol for an adult is ___ mg/kg.

TxWes Ref range: __ to ___mg/kg.

Answer 4

PP: 2 mg/kg IV

TexWes Ref: 1.5-2.5 mg/kg

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Question 5

For sedation, the dose range of Propofol is __ to __ mcg/kg/min.

Answer 5

25–100 mcg/kg/min

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Question 6

The typical dose range of Propofol for Total Intravenous Anesthesia (TIVA) is __ to __ mcg/kg/min.

Answer 6

100–300 mcg/kg/min

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Question 7

True or False

Propofol is a controlled substance

Answer 7

False

Question 8

A pretreatment with __________ can help reduce pain on injection with Propofol.

Answer 8

1–2% Lidocaine

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Question 9

Which of the following statements are true about Propofol’s pharmacokinetics?
Select 3

A) It has a high protein-binding capacity
B) It always requires dose adjustments in patients with renal or liver disease.
C) It is highly accumulative with short-term use.
D) The patient is unconscious within 30 seconds of administration.
E) Propofol is a titratable drug
F) Increased dose for elderly patients

Answer 9

A) It has a high protein-binding capacity (98%)
D) The patient is unconscious within 30 seconds of administration.
E) Propofol is a very titratable drug

Doses rarely need to be changed with renal or liver disease.

Accumulates with long therapy.

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Question 10

The context-sensitive half-time of Propofol is > ____ minutes and does accumulate with long therapy.

Answer 10

> 40 minutes

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Question 11

Propofol’s elimination half-life ranges between __ to __ hours.

Answer 11

0.5 to 1.5 hours

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Question 12

Which of the following is an additional benefit of Propofol aside from its sedative properties?

A) Bronchodilation
B) Vasoconstriction
C) Muscle relaxation
D) Anticoagulant effects

Answer 12

A) Bronchodilation

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Question 13

Propofol is considered the best drug to blunt the laryngeal response during which procedure?

A) Endoscopy
B) Bronchoscopy
C) Laryngoscopy
D) Colonoscopy

Answer 13

C) Laryngoscopy

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Question 14

In low doses Propofol can be used as a rescue medication to treat __________.

Answer 14

C) PONV Postoperative nausea and vomiting

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Question 15

Propofol Infusion Syndrome

Rare problems with Propofol are normally caused by:
Select 3
A) High-dose Propofol infusion (≥ 5 mg/kg/hr)
B) Short-term use in minor surgeries
C) Use in critically ill patients with head injuries
D) Low-dose Propofol infusion ( < 5 mg/kg/hr)
E) Extended infusion duration (> 58 hours)

Answer 15

A) High-dose Propofol infusion (≥ 5 mg/kg/hr)
C) Use in critically ill patients with head injuries
E) Extended infusion duration (> 58 hours)

Critically ill adults with head injuries receiving long term (> 58 hours) and high dose infusions (5 mg/kg/hr)

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Question 16

Propofol Infusion Syndrome

Which of the following conditions are associated with long-term, high-dose Propofol infusion?
Select 2
A) Lipidemia
B) Hypercalcemia
C) Hypotriglyceridemia
D) Fatty infiltrates of the liver
E) Low lactate levels

Answer 16

A) Lipidemia
D) Fatty infiltrates of the liver

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Question 17

Propofol Infusion Syndrome

Which of the following is a metabolic disturbance associated long term, high dose propofol infusion?

A) Respiratory alkalosis
B) Metabolic acidosis
C) Respiratory acidosis
D) Metabolic alkalosis

Answer 17

B) Metabolic acidosis

Propofol causes metabolic acidosis primarily through mitochondrial inhibition → impaired oxidative phosphorylation → anaerobic metabolism and lactic acidosis

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Question 18

Propofol Infusion Syndrome

Signs or symptoms of receiving long term, high dose infusions of propofol tend to develop:
Select 3

A) Myoglobinuria
B) Hypoglycemia
C) Enlarged liver
D) Rhabdomyolysis.
E) Metabolic alkalosis

Answer 18

A) Myoglobinuria
C) Enlarged liver
D) Rhabdomyolysis.

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Question 19

True or False

Propofol Infusion Syndrome can lead to sudden onset of bradycardia that progresses to asystole and is resistant to treatment.

Answer 19

True

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Question 20

Tex Wes Ref: The onset time of propofol is __ to __ seconds.

Answer 20

30 to 60 seconds

Question 21

Tex Wes Ref: The duration of action time of propofol is __ to __ minutes.

Answer 21

1 to 8 minutes