Narcotics: Morphine

Question 1

Morphine is classified as an __________, meaning it binds to and activates opioid receptors.

Answer 1

Agonist

Throw back to Dr. T

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Question 2

PP & TexWes Ref: What is the typical IV dose range for Morphine when used for post-operative pain management?

Answer 2

5-20 mg titrated

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Question 3

After intrathecal administration, Morphine can cause delayed respiratory depression lasting up to __________ hours.

Answer 3

24

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Question 4

Morphine has dose-dependent release of which chemical that may lead to side effects?

Answer 4

Histamine

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Question 5

With high doses, Morphine can lead to a decrease in __________.

A) PVR
B) Heart rate
C) Respiratory rate
D) Blood pressure

Answer 5

B) Peripheral vascular resistance (PVR)

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Question 6

In patients with liver failure, renal failure, or advanced age, Morphine’s half-life is:

A) Shortened
B) Unaffected
C) Prolonged
D) Doubled

Answer 6

C) Prolonged

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Question 7

True or False

Morphine has 2 active metaboiltes

Answer 7

True

Morphine-6-glucuronide (M6G)
More potent than morphine and is responsible for the analgesic effect of morphine

Morphine-3-glucuronide (M3G)
An inactive metabolite that may produce excitatory effects and is responsible for some side effects of high-dose morphine

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Question 8

TexWes Ref: Morphine Intra op dose is ___ mg.

Answer 8

1-10 mg

Question 9

TexWes Ref: The onset for Morphine is ___ min.

Answer 9

10-20 minutes

Question 10

TexWes Ref: The duration of Morphine is __ to __ hours.

Answer 10

4-5hours