IVIg

Question 1

📦 General Info

Answer 1

• Blood product prepared from pooled serum of 10,000–15,000 donors per batch
  
  • Acts as:
  • Immunoglobulin replacement
  • Immunomodulatory agent

Question 2

⚙️ Mechanisms of Action

Answer 2

• Modulates:
• T cells
• B cells
• Macrophages
• Complement system
• Cytokine networks

. * Reduces:
- Antibody production
- Antibody degradation

Question 3

🧪 IVIg Action

Answer 3

4 Separate Components
1. Variable region activity
2. Fc region activity on multiple receptors
3. Complement binding via Fc fragment
4. Unclear immune-modulatory substances in some IVIg preps

Question 4

💊 Dosing

Answer 4

• Replacement dose: 200–400 mg/kg every 3–4 weeks (for immunodeficiency)
  
  • High dose: 1–2 g/kg/month (as immunomodulatory agent)

Question 5

💉 Indications for IVIg

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Answer 5

🩸 Hematological
* ITP (Immune Thrombocytopenic Purpura)
* Post-plasmapheresis (e.g., myasthenia)
* APLS (Antiphospholipid Syndrome)
* Chronic GvHD (hypogammaglobulinemia)

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🔥 Vasculitis
* Microscopic polyangiitis
* Kawasaki disease
* Wegener’s granulomatosis (Granulomatosis with polyangiitis)

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🧠 Neuromuscular
* GBS / AIDP (Guillain-Barré syndrome / Acute Inflammatory Demyelinating Polyradiculoneuropathy)
* CIDP (Chronic Inflammatory Demyelinating Polyneuropathy)
* MG (Myasthenia Gravis)
* Dermatomyositis
* Lambert-Eaton Myasthenic Syndrome
* MS (Multiple Sclerosis)

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🧖 Dermatological
* Pemphigus vulgaris
* Bullous pemphigoid
* SJS / TEN – controversial use

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🦠 Infectious (Less Evidence)
* Streptococcal infections
* Staphylococcal infections