junctions

Question 1

tight junctions

Answer 1

• define polarity
• control passage of substances
• can link actin to cytoskleton

Question 2

what are tight junctions made of?

Answer 2

claudins and occludin proteins

Question 3

adherens junctions?

Answer 3

• plaque anchors the actin filaments at the membrane
• different cadherin proteins will provide cell adhesion in different tissues

Question 4

E-cadherin

Answer 4

epithelia

adherens junctions

Question 5

N-cadherin

Answer 5

neurons and heart muscle

Question 6

p-cadherin

Answer 6

placenta an epidermis

Question 7

VE- cadherin

Answer 7

endothelial cells

Question 8

in adherens junctions, what does cadherins link to actin via?

Answer 8

catenin

Question 9

what are the 2 things that make up a desmesome?

Answer 9

plaque and filaments

Question 10

desmesome plaque?

Answer 10

cytoplasmic dense plaque containing desmoplakin and plakoglobin proteins

Question 11

desmosome filaments?

Answer 11

keratin filaments anchored to the cytoplasmic dense plaque.

Question 12

What does focal adhesions link the outside of the cell with the cytoskeleton via?

Answer 12

transmembrane proteins called integrins

Question 13

what are integrins

Answer 13

they are proteins that bridge the gap between the cytosol and the ECM

Question 14

in duchennes muscular dystrophy, what is there are absence of?

Answer 14

dystrophin adaptor due to premature termination of translation

Question 15

how does microinvasive carcinoma work?

Answer 15

• carcinoma in situ cells convert to mesenchymal cells
• expression of cadherin is reduced
• invasion is aided by protrusions called invadipodia
• secretion of metalloproteases
• bm breached