Ketamine

Question 1

Ketamine

Mechanism of Action:

Answer 1

NMDA receptor antagonist (antagonizes glutamate)
secondary receptor target: opioid, MAO, serotonin, NE, muscarinic, Na⁺ channels.
Dissociates the thalamus (sensory) from the limbic system (awareness).

Question 2

Ketamine

Class:

Answer 2

Arylcyclohexylamine

Question 3

Ketamine

Induction Dose:

Answer 3

IV - 1-2mg/kg
IM - 4-8 mg/kg
PO - 10mg/kg

Question 4

Ketamine

Bolus Dose:

Answer 4

0.1-0.5mg/kg

Question 5

Ketamine

Gtt rate:

Answer 5

1-3mcg/kg/min (opioid sparing effect)

Question 6

Ketamine

Common Side Effects/ Contraindications:

Answer 6

Increased: HR, SNS tone, CO, SVR, PVR
severe CAD,
severe RV failure,
avoid with acute intermittent porphyria

Question 7

Ketamine

Onset IV/IM

Answer 7

IV - 30-60 sec
IM - 2-4 min

Question 8

Ketamine

Peak:

Answer 8

IV- 1min
IM - 5min

Question 9

Ketamine

Distribution half-life:

Answer 9

10-20min

Question 10

Ketamine

Metabolism:

Answer 10

Hepatic CYP450 Enzymes

Question 11

Ketamine

Elimination half-life/Active metabolites:

Answer 11

2-3hrs
norketamine: 1/3-1/5 potency