Merperidine

Question 1

Merperidine

Mechanism of Action:

Answer 1

Mu opioid receptor agonist, also acts at the kappa receptor

Question 2

Merperidine

Class:

Answer 2

Opioid

Question 3

Merperidine

Bolus Dose:

Answer 3

12.5 - 50mg - normally given for shivering

Question 4

Merperidine

Common Side Effects/ Contraindications:

Answer 4

Respiratory depression,
N/V

those on MAOIs,
renal or liver dysfunction due to the metabolite (eliminated by kidneys and liver),
Chlorpromazine (increased respiratory depressant effects)

Question 5

Merperidine

Onset:

Answer 5

5 min

Question 6

Merperidine

Peak:

Answer 6

15 min

Question 7

Merperidine

Distribution half-life:

Answer 7

2-3hrs

Question 8

Merperidine

Metabolism:

Answer 8

CYP3A4 - Hepatic

Question 9

Merperidine

Elimination half-life/Active metabolites:

Answer 9

3hrs/
normeperidine - 1/2 the analgesic effect and 2-3x the CNS effects of meperidine and has elimination half-life of 15-20hrs