Ketogenesis

Question 1

Location

Answer 1

made in liver mitochondria

energy for extra hepatic tissue

Question 2

1. Acetyl CoA + Acety CoA -> Acetoacetyl-CoA

Answer 2

• CoASH
• condensation
• reversible
• enzyme: THIOLASE

Question 3

2. Acetoacetyl-CoA -> B-Hydroxy-B-methylglutaryl-CoA

Answer 3

Acetoacetyl-CoA + Acetyl CoA + H2O-> HMG-CoA + CoASH

• condensation
• enzyme: HMG-CoA SYNTHASE

Question 4

3. HMG-CoA -> Acetoacetate

Answer 4

• acetyl CoA
• cleavage
• enzyme: HMG-CoA LYASE

Question 5

4. Acetoacetate -> Acetone

Answer 5

• decarboxylation
• spontaneous
• enzyme: ACETOACETATE DECARBOXYLASE
• infequently
• toxic
• breath it out

Question 6

5. Acetoacetate -> D-B-hydroxybutyrate

Answer 6

• reduction
• NADH->NAD+
• reversible
• enzyme: D-B-HYDROXYBUTYRATE DEHYDROGENASE