Ketolysis

Question 1

Location

Answer 1

peripheral tissue

• skeletal muscle
• heart
• renal cortex
• brain

Question 2

Total energy yield

Answer 2

21,5 mol ATP

• 20 ATP from acetyl CoA
• 2,5 ATP from NADH
• 1GTP

Question 3

1. D-B-hydroxybutyrate -> Acetoacetate

Answer 3

• oxidation
• NAD+ -> NADH
• enzyme: D-B_HYDROXYBUTYRATE DEHYDROGENASE

Question 4

2. Acetoacetate -> Acetoacetyl CoA

Answer 4

Acetoacetate + Succinyl CoA -> Acetoacetyl CoA + Succinate

-enzyme: B-KETOACYL CoA TRANSFERASE

Question 5

3. Acetoacetyl CoA -> 2x Acetyl CoA

Answer 5

-cleavage
+CoASH
-enzyme: THIOLASE
-used in TCA