Ketolides

Question 1

Ketolides prototype

Answer 1

Telithromycin (Black Box warning for myasthenia gravis b/c it exacerbates respiratory problems).

Question 2

Telithromycin indications

Answer 2

Treatment of community-acquired pneumonia caused by susceptible bacteria.

Question 3

Telithromycin actions

Answer 3

Binds to bacterial ribosomes, altering protein function and leading to bacterial cell death.

Question 4

Telithromycin route, onset, peak

Answer 4

Oral, rapid 0.5-4 h

Question 5

Telithromycin T 1/2

Answer 5

10 hours; metabolized in the liver and excreted in the feces and urine.

Question 6

Telithromycin adverse effects

Answer 6

Headache, dizziness, nausea, vomiting, pseudomembranous colitis, superinfections.