Monobactam

Question 1

Monobactam prototype

Answer 1

Aztreonam

Question 2

Aztreonam indications

Answer 2

Treatment of lower respiratory, dermatological, urinary tract, intra-abdominal, and gynecological infections caused by susceptible strains of gram-negative bacteria.

Question 3

Aztreonam actions

Answer 3

Interferes with bacterial cell wall synthesis, causing cell death in susceptible gram-negative bacteria, is not effective against gram-positive or anaerobic bacteria.

Question 4

Aztreonam route

Answer 4

IM, varies, 60-90 min, 6-8 h;

IV, immediate, 30 min, 6-8 h

Question 5

Aztreonam T 1/2

Answer 5

1.5 to 2 hours; excreted unchanged in the urine.

Question 6

Aztreonam adverse effects

Answer 6

Nausea, vomiting, diarrhea, rash, superinfection, anaphylaxis, local discomfort at injection sites.