L8: Permability Models

Question 1

Which statement is FALSE for drug requirements?
- Should reach absorption place
- Time frame is not important
- Target site is important
- Reproducibility is important

Answer 1

Time frame is not important

Question 2

Permeability is the ability of a drug to transport across biological barriers.
True or false?

Answer 2

True

Question 3

Drug absorption is the movement of a drug into the stomach?
True or false

Answer 3

False

Question 4

Undissolved drug contributes to absorption.

True or false

Answer 4

False

Question 5

What drives drug absorption?

• blood pressure
• concentration gradient between blood and intestine
• patient demographics

Answer 5

Concentration gradient between intestine and blood

Question 6

The route of administration can improve drug absorption
True or false

Answer 6

True

Question 7

What can you NOT use PAMPA for?

• Fast and easy
• standardized and few variabilities
• stimulating in vivo accurately
• Cheap

Answer 7

Stimulating in vivo accurately

Question 8

Which law describes flux?

Answer 8

Fick’s first law

Question 9

BSC class 3 means

Answer 9

Low permeability and high solubility

Question 10

What is FALSE for the closed loop perfusion technique?

• mechanistic understanding
• fast and cheap
• intact mucus layer
• blood flow and motility of the intestine

Answer 10

Cheap and fast

Question 11

When using Franz cells, biorelevant media cannot be used:
True or false

Answer 11

False