Lec 33

Question 1

What is dysbiosis?

Answer 1

Loss/perturbation of normal microbiome homeostasis

Question 2

Why did genetically identical mice respond differently to infection?

Answer 2

Differences in their microbiomes

Question 3

What is the difference between microbiota and microbiome?

Answer 3

Microbiota = organisms; microbiome = their genomes

Question 4

Name factors that factors that influence microbiome development

Answer 4

genetics, birth, environment, lifestyle

Question 5

T/F Microbiome development is not dynamic

Answer 5

FALSE

Question 6

How understood is microbiome development?

Answer 6

Not very understood

Question 7

Why is microbiome not passively stable?

Answer 7

Changes with age

Responds to immune system changes

Requires active immune regulation

Question 8

Microbiome needs what type of regulation?

Answer 8

active immune regulation

Question 9

How does aging affect microbiome homeostasis?
A

Answer 9

Reduced immune regulation increases disease risk

Question 10

Name two ways microbiota help prevent infection

Answer 10

Colonization resistance; immune activation