lecture 1 Flashcards

(51 cards)

1
Q

what is the alveolar epithelium?

A

walls of the alveoli

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2
Q

where is the site of gas exchange?

A

at the capillaries between the alveoli

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3
Q

the opening of the trachea is called the

A

glottis

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4
Q

how many lobes does the right and left lung have respectivly

A

right has 3 and left has 2

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5
Q

why does the left lung have only 2 lobes?

A

because it has the cardiac notch to create more space for the heart

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6
Q

the conducting zone is a site for anatomical dead space. what is in the conducting zone from start to finish?

A

trachea - primary bronchi - secondary lobar bronchi - tertiary segmental bronchi - and terminal bronchioles

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7
Q

in the respiratory zone, the walls are thin enought for what to occur?

A

gas exchange

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8
Q

what structures are present in the respiratory zone from start to finish?

A

respiratory bronchioles, alveolar ducts , alveolar sacs, and alveoli

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9
Q

restrictive diseases primary effect what part of the lungs?

A

the respiratory zone/ alveoli

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10
Q

obstructive diseases thypically effect which part of the lungs?

A

the upper airways/ conducting zone

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11
Q

the interpleural space contains _____ and has what type of pressure?

A

contains pleural fluid and has negative pressure at around -4 cm H2O at rest

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12
Q

what are the regional differences in intrapleural pressure?

A

the pressure is more negative at the lungs apex and less negative at the lungs base

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13
Q

because of the pressure gradient, after a normal exhalation (FRC), why does fresh air mostly flow to the lungs bases?

A

because the pressure is more negative in the apices the alveoli located there are already fully expanded meaning no more air can flow in. in the bases the alveoli are not expanded so fresh air will mostly flow into the alveoli in the bases

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14
Q

after a forced exhalation, fresh air will primarily go to the apex alveoli, why is this?

A

because the residual volume is primarily in the bases and the alveoli there traps the gas. the alveoli in the apex is not full of trapped air so they are the first to receive fresh air.

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15
Q

what is the lung hilum aka the lung root?

A

this is the entry and exit point for bronchi, pulmonary arteries and veins, lymphatics, and nerves

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16
Q

where do lung tissue and bronchi receive their blood supply from?

A

the bronchial arteries which branches from the aorta

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17
Q

where does the deoxygenated blood from the bronchial circulation drain?

A

into the left atrium

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18
Q

what is the physiological consequence of the deoxygenated blood from the bronchial circulation being dumped into the left atrium?

A

deoxygenated blood mixes with oxygenated blood and dilutes the blood dropping the arterial PO2 by 2 or 3 mmHg

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19
Q

what are the boundaries of the thoracic cavity in the posterior, anterior, and lateral planes?

A
  • thoracic vertebrae
  • sternum (ends at xiphoid process)
  • ribs and cotal cartilage
    respectivly
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20
Q

what does it mean when you look at a lung CT/Xray and see a mostly black lung, Ground glass opacity, or condensation shadows?

A
  • lung is filled with air
  • alveoli is partially filled
  • alveoli is filled with fluid
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21
Q

what respiratory muscles are used for expiration?

A
  • internal intercostals and abdominal muscles
22
Q

which muscle was considered an accessory muscle in breathing but is now considered a primary muscle?

A

scalenes, because they are active in every breath

23
Q

what are the muscles of inspiration?

A
  • sternocleidomastoid
  • scalenes
  • external intercostals
  • interchondral part of internal intercostals
  • diaphragm
24
Q

which muscles are responsible in elevating the ribs?

A

the scalenes and intercostal muscles and diaphragm

25
other than elevating the ribs, what else does the diaphragm do with regards to inspiration?`
it increases vertical dimension of the thoracic cavity
26
what is the interchondral part of the intercostals?
its the muscles where the ribs become cartilage
27
what muscles are involved in expiration?
the internal intercostals and abdominal muscles
28
typically expiration is a passive process and is driven by elastic recoil. when might accessory muscles be used during expiration?
- during exercise - obstructive lung diseases eg. COP and asthma
29
in obstructive disease patients, there is an increase in expiratory effort. this is because there is an increase in intrapleural pressure. if intrapleural pressure exceeds airway pressure, what happens to the respiratory zone (smaller airway)
it compresses and collapse
30
what is the defienition of equal pressure point (EPP)?
this is the point where the airway pressure = interpleural pressure
31
what is the crura?
these are tendon like structures that extends below the diaphragm and attaches it to the vertebrae
32
what does the central tendon attach?
it attaches the diaphragm to the pericardial sac
33
what is the auricle?
it is a muscular extension of the atrium that has SNS and PSNS regulation
34
where does the phrenic nerve originate and why is it important?
- it originates from C3 - C5 - it provides motor innervation to the diaphragm and keeps it alive
35
where are the capillaries located in the respiratory zone?
they are sandwiched between the alveoli in the alveolar septum
36
what is the lung parenchyma?
the part of the lung comprised of the alveoli, capillaries, and elestic connective tissue
37
what are type 1 pneumocytes?
they are thin and flat and most abundant. they are involved in gas exchange
38
what are type 2 pneumocytes?
they are cuboidal and secrete surfactant to help repair the lungs
39
what is the function of elastin and collagen in the the lungs?
they stretch during inspiration and recoils during passive expiration
40
what are pores of kohn?
they are small openings between adjacent alveoli and allows for collateral ventilation and gas exchange
41
why are pores of khon important
they allow for gas exchange in conditions where some alveoli are blocked and allow for macrophage migration for immune defense
42
where in the lungs is the key site for disease manefestation?
the alveolar septum
43
restrictive diseases are diseases that have to do with inspiration. it falls under three categories. what are they?
1. chest wall disease (muscular disorder) 2. pleural disease 3. interstitial disease
44
what is the interstitial space?
the area between the alveolar epithelium and capillary endothelium
45
fibroblast infiltration is an example of interstitial disease. it lays down more fibrous material such as collagen in the interstitial space. what are the consequences of this.
- it increases diffusion distance for gasses and the lungs become more stiff which makes it harder for the alveoli and lungs to expand
46
how does immune activity take place in the alveolar septum and what is consequence of this immune activity?
1. immune cells infiltrate the interstitial space during infection 2. inflammatory mediators are released 3. the cappilary endothelium becomes leaky and fluid leaks into the alveoli resulting in pulmonary edema
47
how do you calculate alevoolar pressure?
inward elastic recoil pressure + outward intrapleural pressure
48
what are and unfortunate consequence of pores of kohn?
it can allow for the spread of infection, inflammation, and pathogens
49
for oxygen to cross into the blood what is the barriers in its way at the alveoli?
1. surfactant layer 2. alveolar epithelium 3. interstitial space 4. capillary endothelium
50
what are canals of lamber and what do they allow for?
they are a connection between bronchioles and adjacent alveoli. they also allow for alternate airflow during obstructions
51
what are channels of martin and what do they do?
they are connections between bronchioles and help distribute ventilation across airway regions