Lecture 13

Question 1

What the central limit theorem

Answer 1

Theorem that suggests that even if you have a large number of identical and independent variables tends to approach a normal distribution, this bell shape, due to things like environmental factors
Not all of these individuals will suffer from environmental factors or the same factors or to the same extend, that explains the variety in phenotype
This applies to complex genetic traits

Question 2

What does Vx stand for

Answer 2

Phenotypic variance, how much a population physically differs, can be due to genetic or environmental factors

Question 3

What are Vg and Ve

Answer 3

Environmental and genetic variance, these together make up Vx, phenotypic variance

Question 4

Broad sense heritability

Answer 4

H^2= Vg/Vx
H^2 is a symbol not actually squared, Vg is genetic variance and Vx is phenotypic variance aka Vg+ Ve
Basically a measure of how much of the phenotypic variability in a trait is due to genetic component

Question 5

What’s QTL mapping

Answer 5

Quantitative trait loci
It’s a take on the classical mapping approach (doing controlled crosses then tracking which molecular markers show up with what phenotype to narrow down where the gene is)
Key is starting with inbred lines such that they show opposite phenotypes, this will mean that theyre likely homozygous for whatever complex trait theyre expressing, F1 will be something in teh middle, makes sense they’ll be heterozygous, but F2 will vary much more due to crossing over, giving progeny with much higher genetic variance