Lecture 14

Question 1

GWAS

Answer 1

Genome wide association studies
When you survey a population, get sample populations as opposed to controlled crosses
You can map genome of those that are affected by a disease and see how many of them also have a certain molecular marker, then you can statistically check whether this linkage happens often enough to be considered close in the genome or just coincidental, but the thing is since many generations have passed in a population and weve had lots of crossing over, youre likely to have something actually close by

Question 2

What’s a weakness of QTL

Answer 2

Since youre looking at two very specific individuals (totally recessive for a multi gene trait and totally dominant) you can be missing out on different genetic variants, something that can be seen populationally in GWAS
Also the fact that every offspring produced has one meiotic event so there isn’t that much crossing over to get very diverse, we have blocks of genes moving around and not substantial shuffling, so hard to pinpoint the exact location of a gene if were tracking these broad chunks