Lecture 15

Question 1

Pharmaceutical Strategies

Answer 1

• abuse deterrent technologies are designed to make product manipulation more difficult or to make abuse of manipulated product less attractive
• improve physical tamper resistance (oxycontin, Exalgo)
• Incorporate deterrent (suboxone, embeda)

MUST BE REFERENCED

Question 2

Abuse Deterrent Formulation

Answer 2

Inactive Ingredients
- Hypromellulose (Polymer)
- Polyethylene Glycol (Solvent)
- Polyethylene Oxide (Polymer) –> KEY
- Magnesium Stearate (Lubricant)
- Titanium Dioxide (Pigment)

Question 3

Old vs New

Answer 3

Old
- crush it and add water to it
- withdraw it in insulin syringe
- easy to abuse and never knew the dose

New
- forms a gel
- cannot really withdraw in syringe unless you crush and microwave for 7 minutes

Question 4

PEO Method

Answer 4

• developed by McGinity and Zhang in Texas
• both doses of extended release went out for 12 hours; however, one of them was released at a higher rate
• PEO was very hard and wouldn’t break when chewed

Question 5

PEO Structure

Answer 5

• net like structure that water filled the gaps