what is nucleosome remodeling?
the changing in position of the nucleosome resulting in sliding, displacing and recruiting during gene expression
what is constitutive heterochromatin?
chromatin remains in the compacted state at all time; DNA is permanently silenced
what is facultative heterochromatin?
chromatin that has been specifically inactivated during certain stages of an organisms life or certain cell
what can the compaction chromatin create?
compaction of chromatin can create TADs (topologically associated domains)
what are TADs?
a region of genome sequences that don’t interact with its proximal part but instead interact with a distal part based on how it is wrapped
why should we care about wrapping DNA
The amount of DNA does not equal the amount genes it can vary
what are the 5 non coding functional RNAs ?
- tRNAS
- piRNAS
- IncRNA
- snRNAs
- snoRNA
what are 4 gene related sequences ?
- Pseudogenes
2.Introns
3.Untranslated regions - Gene fragments
what is the percentage of intergenic genes in eukaryote ?
60%
what are transposable elements ?
elements of DNA that can move from- one genomic location to another leaving an original copy behind
what are two major categories of transposable elements(JUNK) and how do they move ?
DNA transposons- move by cut and paste
DNA- Retrotransposons- move by copy and paste
what are two type of retrotransposons ?
SINEs- short interspersed nuclear elements
LINEs- long interspersed nuclear elements
what are two repeat types (junk DNA)?
- Satellites (VNTRs)- short sequences 5-100 bp that form linear arrays with millions of DNA bp used in paternity testing
- Short Tandem repeats (STRs) 2-6 bp for array of 50-500 bp ; used in forensics
What fraction of the euk genome contains the most genome info
1. 60%
2.18%
3.10%
4. 2%
- 2% bc that is the coding amount in euk
