Lecture 3 -- Smallpox

Question 1

Smallpox Pathway

Answer 1

1. Variola virions are inhaled
2. Virions travel/ are transported to lymphoid organs
3. Virions infect macrophage and undergo early replication
4. Infect macrophage enter the bloodstream

Question 2

Lymphoid Organs

Answer 2

Spleen
Bone Marrow
Lymph Nodes

Question 3

Smallpox Pathway: The skin

Answer 3

1. Infected macrophage travel to the small vessels in respiratory mucosa and dermis
2. Macrophage migrate to the epidermis and infect basal cells
3. Basal cell infection leads to cellular necrosis and localize edema

Question 4

Incubation Period

Answer 4

1. Incubation period: 12 days (7-19 days)
2. Virus undergoing early replication in macrophage within Lymphoid Organs
3. NOT infectious

Question 5

Prodrome Period

Answer 5

1. Infected macrophage entering tissues
2. Abrupt onset of fever >101 F
3. Malaise, headache, muscle pain, nausea, vomiting, backache
4. Becomes infectious during this period

Question 6

Enanthem Period

Answer 6

1. Mucous membrane lesions
2. Appears – 24 BEFORE skin rash
3. Becomes infectious from lesions in mouth

Question 7

Exanthem Period

Answer 7

1. Skin rash
2. Macules, papules, vesicles, pustules, scabs
3. Centrifugal distribution