Lecture 5

Question 1

Intracellular pathogens are captured and presented by Class ___ MHCs, while extracellular pathogens are captured and presented by Class ___ MHCs

Answer 1

I, II

Question 2

The ___ was originally discovered as the principle determinant of graft rejection

Answer 2

MHC locus - people with different MHCs reject tissue grafts

Question 3

The MHC locus is a set of ___ genes

Answer 3

Highly polymorphic - many different Class I and Class II molecules that display peptides to T cells

Question 4

MHC - peptide interaction (anchor residues and what the TCR recognizes)

Answer 4

2-3 amino acids of the antigenic peptide fit into the MHC peptide-binding cleft (anchor residues), the TCR recognizes the amino acid residues that extend upwards

Question 5

Class II MHC expressing cell types (3):

Answer 5

Macrophages, B cells, dendritic cells

Question 6

Class I MHC expressing cell types:

Answer 6

All nucleated cells