Lecture 6

Question 1

The Blood Brain Barrier Is a 2 fold entity Between…

Answer 1

1. Blood Vessels & Interstitial Fluid
2. Blood Vessels & CSF

Question 2

3 factors of Brain Encasing

Answer 2

1. Skull
2. Meninges
3. Reticular Formation

Question 3

Blood-Brain Barrier

Answer 3

The endothelial lining of the blood vesicles contain mostly large gaps-

Question 4

Fenestrations

Answer 4

pores in which molecules can pass

Question 5

Important features of the endothelial cells in the brain

Answer 5

it contains no pores (this is what makes up the BBB, everything has to be transported)

Question 6

Meninges

Answer 6

Three layers of membranes known as meninges protect the brain and spinal cord.

Question 7

3 layers of the meninges (outside-inside)

Answer 7

1. Dura Mater
2. Arachnoid membrane
3. Pia mater

Question 8

Ventricles

Answer 8

cavities deep inside the brain which are filled with CSF (which is the bathing medium of brain- highly regulated ionic content and few macromolecules)

Question 9

Cerebral spinal fluid is produced by the ________

Answer 9

choroid plexus (and lines the ventricles)

Question 10

Arachnoid Villi

Answer 10

an out pouching of the arachnoid tissue

Question 11

Choroid Plexus

Answer 11

produces most CSF but not all- about 550 ml/day (some CSF is produced in the capillaries inside the brain)

Question 12

CSF (cerebral-spinal fluid)

Answer 12

• Fills the ventricles and the subarachnoid space
  
  • Has same osmolarity and [Na+] as blood
  • LOW [K+], [Ca2+] and [Mg2+]

Question 13

Astrocytes

Answer 13

provide a bridge between neurons and blood vessels

Question 14

A Lumbar Puncture

Answer 14

(spinal tap) is a diagnostic, therapeutic procedure to collect a sample of CSF for analysis

Question 15

2 functions of astrocytes

Answer 15

1) Remove neurotransmitters
2) Provide energy substrates