LIPIDS Flashcards

(77 cards)

1
Q

exist as short, medium, and long chains of molecules
that are major constituents of triglycerides and
phospholipids

A

Fatty acids

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2
Q

simply linear chains of c-h bonds that terminate with a
carboxyl group (-COOH)

A

Fatty acids

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2
Q

can be extracted fr. cells only by organic solvents

A

LIPIDS

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3
Q

formed from one glycerol molecule with three fatty
acids molecules attached via ester bonds

A

Triglycerides

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4
Q

transported through the body by chylomicrons(exogenous) and VLDL (very-low-density

A

Triglycerides

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5
Q

metabolism of tiglyceride

A
  • metabolism: TG -> (lipase) 3 FA and 1 Glycerol
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6
Q

unsaturated steroid alcohol containing four rings

A

Cholesterol

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7
Q

precursor for synthesis of bile acids, steroid/sex
hormones, and vit. D

A

Cholesterol

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8
Q

-LDL is the primary carrier

A

cholesterol

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9
Q

2 fatty acids + glycerol linked by ester bonds

A

Phospholipids

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10
Q

found on the surface of lipid layers, they are major
constituents of cell membranes and outer shells of llipoprotein molecules

A

Phospholipids

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11
Q

transport vehicles for lipids that contain varying
amounts of specific lipid, phospholipid and apoprotein

A

Lipoproteins

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12
Q
  • largest lipoproteins and have the lowest density
A

Chylomicrons

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13
Q

transport triglycerides after a meal

A

Chylomicrons

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14
Q

plasma-turbid/milky with creamy layer (chylomicrons
float on top) (frappe daw) (cotton)

A

Chylomicrons

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15
Q

apolipoprotein B-48 (Apo B48) (to make the lipids more
soluble to the blood for east transport)

A

Chylomicrons

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16
Q

carries endogenous triglyceride

A

VLDL

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17
Q

APO B100

A

VLDL, LDL

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18
Q
  • “VLDL remnants”, transitional form
A

Intermediate-density lipoprotein (IDL)

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19
Q

elevated in type III hyperlipoproteinemia
(dysbetalipoproteinemia or broad beta disease)

A

Intermediate-density lipoprotein (IDL)

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20
Q

delays the clearance of IDL

A

Apo E

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21
Q

high risk of coronary heart disease

A

IDL

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22
Q

“bad cholesterol”

A

Low-density lipoprotein (LDL)

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23
Q

major cholesterol carrier

A

Low-density lipoprotein (LDL)

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24
- apolipoprotein B-100
Low-density lipoprotein (LDL)
25
- "good cholesterol"
High-density lipoprotein (HDL)
26
has antiatherogenic effect
High-density lipoprotein (HDL)
27
apolipoprotein A-1
High-density lipoprotein (HDL)
28
composed primarily of cholesterol esters, phospholipids
Lipoprotein a
29
- apolipoprotein a
Lipoprotein a
30
increased in coronary heart disease and myocardial infarction
Lipoprotein a
31
- increased in atherosclerosis
LDL
32
HIGH RISK OF CHD
IDL
33
increased in coronary heart disease and myocardial infarction
Lipoprotein a
34
- abnormal lipoprotein
Lipoprotein X
35
- biliary cirrhosis or cholestasis and genetic lecithin-cholesterol acyltransferase (LCAT) Deficiency
Lipoprotein X
36
- genetic lipid abnormality "FH" most closely linked to heart disease
Hypercholesterolemia
37
- FH (genetic), or the result of secondary hormonal abnormalities (DM & renal disease)
Hypertriglyceridemia
38
moderately elevated tri, VLDL,, normal LDL, Decreased HDL
familial Hypertriglyceridemia
39
- presence of elevated levels of serum total cholesterol and triglycerides
combined hyperlipidemia
40
- high total cholesterol, high triglycerides, high LDL, low HDL
familial combined hyperlipidemia (FCH)
41
Diabetes mellitus, hypothyroidism, obesity, pregnancy, nephrotic syndrome, pancreatitis, alcoholism
Secondary lipoproteinemia -
42
- elevated VLDL and Apo B- 100, normal to elevated LDL, normal or elevated triglycerides decreased HDL chole and Apo A1
Hyperapobetalipoproteinemia
43
how is hdl measured
Precipitation of LDL and VLDL/Polyanion Precipitation, followed by measurement of HDL in supernatant
44
PRECIPITATING AGENT OF HDL
Precipitating agent: sulfate-magnesium chloride sulfate-manganese chloride
45
WHERE IS FRIEDEWALD FORMULA USED AND DESCRIBE IT
Friedewald formula (indirect, not valid for triglycerides over 400mg/dL) LDL cholesterol = total cholesterol - [HDL cholesterol + triglyceride/5]
46
uses detergents to block HDL and VLDL from reacting with the dye to form a colored chromogen product.
Homogeneous assay - use
47
DENSITY OF CHYLOMICRONS
<0.96
48
VLDL DENSITY
<1.006
49
LDL DENSITY
1.006 - 1.063
50
HDL DENSITY
1.006 - 1.21
51
Reference method for cholesterol determination :
Abell-Kendal
52
FREDRICKSON'S HYPERLIPOPROTEINEMIA WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE 1 AND HOW RARE IS IT
RARE, CREAMY, HIGH CHYLOMICRONS
53
WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE IIA AND HOW RARE IS IT
CMMON. CLEAR. HIGH LDL
54
WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE IIB AND HOW RARE IS IT
COMMON. CLEAR, HIGH LDL AND VLDL
55
WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE III AND HOW RARE IS IT
RARE. CLOUDY. ABNORMAL LDL AND VLDL
56
WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE IV AND HOW RARE IS IT
COMMON. MILKY. HIGH VLDL
57
WHAT IS THE PLASMA APPEARANCE AND LIPOPROTEIN ABNORMALITY OF TYPE V AND HOW RARE IS IT
RARE. CREAMY/MILKY. HIGH CHYLOMICRONS AND VLDL
58
CHOLESTEROL LEVEL OF TYPE I
NONE/SLIGHT INC
59
CHOLESTEROL LEVEL OF TYPE IIA
EXTREME INC
60
CHOLESTEROL LEVEL OF TYPE IIB
EXTREME INC
61
CHOLESTEROL LEVEL OF TYPE III
MODERATE
62
CHOLESTEROL LEVEL OF TYPE IV
NONE/SLIGHT
63
CHOLESTEROL LEVEL OF TYPE V
SLIGHT
64
TRIGLYCERIDE LEVEL F TYPE 1
EXTREME INCREASE
65
TRIGLYCERIDE LEVEL F TYPE IIA
NO CHANGE
66
TRIGLYCERIDE LEVEL F TYPE IIB
SLIGHT
67
TRIGLYCERIDE LEVEL F TYPE III
MODERATE INC
68
TRIGLYCERIDE LEVEL F TYPE IV
XTREME INC
69
TRIGLYCERIDE LEVEL F TYPE V
MODERATE INC
70
TOTAL CHOLESTEROL REF RANGE
140-200 mg/dl (3.6-5.2mmol/l)
71
HDL-C REFERENCE RANGE
4-75mg/dl (1.0-2.0mmol/l)
72
LDL-C reference range
50-130mg/sl (1.3-3.4mmol/l)
73
triglyceride reference rane
60-150mg/dl (0.7-1.7mmol/l)
74
genetic lipid abnormality “FH” most closely linked to heart disease
HYPERCHOLESTEROLEMIA
75
esult of secondary hormonal abnormalities (DM & Renal Disease)
HYPERTRIGLYCERIDEMIA
76
presence of elevated levels of serum total cholesterol and triglycerides
COMBINED HYPERLIPIDEMIA