Name the Loop diuretics • Bumetanide • Amiloride • Indapamide • Furosemide
* Furosemide
Warnings of loop diuretics • Severe hypovolaemia • Severe renal impairment • Dehydration • Hypokalaemia
Warnings of loop diuretics
• Severe hypovolaemia
• Dehydration
Cautious in loop diuretics • Dehydration • Hyponatraemia • Gout • Hepatic encephalopathy • All of the above
• All of the above
MOA of loop diuretics
• Inhibit Na+/ K+/ Cl- transporter I the ascending loop of henle
• Act on loop of Henle
• Counteract potassium loss
• Dilation of capacitance veins
• Interfere with Cl¬- bonding cotransporter system
• Reduce lumen positive potential arising K+ recycling
Side effects of loop diuretics • Ototoxicity • Gout • Dehydration • All of the above
• All of the above
Monitoring with loop diuretics • Symptoms sign and bodyweight • Potassium concentration • Serum electrolyte • Serum sodium, potassium and renal function
* Serum sodium, potassium and renal function
Uses of loop diuretics • Pulmonary oedema • Hyperkalaemia • Fluid overload in CHF • Other oedema • Fluid overload in angina
Uses of loop diuretics
• Pulmonary oedema
• Fluid overload in CHF
• Other oedema