Interactions of nitrates • Methotrexate • Warfarin • Phosphodiesterase inhibitor • Prednisolone • Antihypertensives
* Antihypertensives
Short acting nitrates name • GTN • ISMN • ISDN • All of the above
• GTN
Warnings with nitrates • SAS • Hypertension • Haemodynamic instability • Hypotension
MOA of nitrates
• Relaxation and vasodilation in arterial smooth muscle
• Relaxation of the venous capacitance vessels
• Increase cardiac preload and left ventricular filling
• Reduce cardiac preload and left ventricular filling
• Dilation of capacitance veins
• Reduce cardiac work and myocardial oxygen demand
SE of nitrates • Tolerance • Bradycardia • Light-headness • Flushing • Palpitations • Hypotension
Long acting nitrates • ISMN • GTN • ISDN • All of the above
• ISMN
Uses of GTN • Acute angina • Prophylaxis of angina • ACS • Pulmonary oedema • All of the above
* ACS
Uses of ISMN • Acute angina • Prophylaxis of angina • ACS • Pulmonary oedema • All of the above
• Prophylaxis of angina
IV nitrates are used for . Acute angina • Prophylaxis of angina • ACS • Pulmonary oedema • All of the above
• Pulmonary oedema
Administration of IV nitrates require monitoring of what • U&E’s • Renal function • eGFR • blood test • Blood pressure
• Blood pressure <90