0
Q
Elimination half life
A
10-20 hours
1
Q
Potency
A
More potent than diazepam or midazolam
2
Q
Lipid soluble
A
Less than diazepam
3
Q
Absorption
A
GI & IM
Dissolved in propylene or polyethylene glycol
4
Q
Clinical effects
A
May outlast diazepam dissociates from the GABA-a slower
5
Q
Metabolized
A
T an inactive metabolite via glucuronide conjugation in the liver to altered by age, liver dysfunction or H2 receptor antagonists
6
Q
Route
A
Excellent PO
0.5-2 mg @ night
0.5-2 mg in the morning
50 mcg/kg
7
Q
Max dose
A
4 mg
8
Q
Anterograde amnesia
A
6 hours
9
Q
Larger doses
A
Produce greate sedation without increased amnesia
10
Q
Elderly
A
Sensitive to BZDs
11
Q
Onset
A
Slow onset limits usefulness as IV PRE-med or Intra-op sedative
