0
Q
Imidazole ring
A
After soluble at a pH less than 4
Closes upon injection and becomes highly lipid soluble
1
Q
Potency
A
2-4 times more potent than diazepam
2
Q
Protein bound
A
96-98%
3
Q
Lipid soluble
A
Rapid uptake by the brain
Redistribution and re-uptake
4
Q
VD
A
1-1.5 L/kg
5
Q
Clearance
A
6-8 ml/kg/min
6
Q
Elimination half life
A
1-4 hours
7
Q
Oxidative hydroxylation
A
In the liver
8
Q
Glucoronide conjugation
A
In the kidneys
9
Q
Excreted
A
Urine
10
Q
Metabolizes
A
Minimally active
11
Q
H2 receptor antagonists added
A
Not affected
12
Q
Cardiac response
A
Minimal and similar to NaP
13
Q
Ventilation
A
Depressed with 0.15 mg/kg dose
14
Q
Renal failure
A
Kemal effects on half life, VD, and clearance
15
Q
CBF
A
Dose related decrease in CBF and CMRO2
16
Q
Placenta
A
Crosses the U-P membrane
