LSD intoxication

Question 1

what are the effects of LSD

Answer 1

Its psychedelic effects usually involve heightening or distortion of sensory stimuli and enhancement of feelings and introspection. It is one of the most potent psychoactive compounds known.

Question 2

how do patients with LSD toxicity commonly present

Answer 2

Patients with LSD toxicity typically present following acute panic reactions (known as bad trips), massive ingestions or unintentional ingestions.

Question 3

what are the psychoactive symptoms of LSD toxicity

Answer 3

• Variable subjective experiences
• Impaired judgements which can lead to injury
• Amplification of current mood which leads to euphoria or dysphoria
• Agitation, appearing withdrawn - especially in inexperienced users
• Drug-induced psychosis

Question 4

what are the somatic symptoms of LSD intoxication

Answer 4

Nausea
Headache
Palpitations
Dry mouth
Drowsiness
Tremors

Question 5

what are the signs of LSD toxicity

Answer 5

Tachycardia
Hypertension
Mydriasis
Paresthesia
Hyperreflexia
Pyrexia

Question 6

what are the investigations when LSD toxicity is suspected

Answer 6

• The diagnosis of LSD toxicity is mainly based on history and examination.
• Most urine drug screens do not pick up LSD.

Question 7

what is the management of LSD toxicity

Answer 7

• agitation: may require benzodiazipines
• psychosis: may require antipsychotics
• supportive care with ventilation etc