LTRA

Question 1

MoA

Answer 1

Blocks action of leukotriene on cysteinyl leukotriene receptor in lungs and bronchi.
Reduces bronchoconstriction + inflammation

Question 2

Examples

Answer 2

Montelukast
Zafirlukast

Question 3

When are they used?

Answer 3

Chronic asthma
Symptomatic relief of hayfever in asthma

Question 4

Side effects

Answer 4

Churg Strauss syndrome
Hepatotoxicity (zafirlukast)

Question 5

Hepatotoxicty

Answer 5

Zariflukast
Counsel patients to report symptoms

Question 6

Churg strauss syndrome

Answer 6

Occurs on withdrawal/reduction of dose.
- Eosionophilia
- Vasculitic rash
- Worsening pulmonary symptoms
- Cardiac complications
- Peripheral neuropathy