Selective B2 agonists

Question 1

MoA

Answer 1

Causes bronchodilation of the bronchi

Question 2

SABA

Answer 2

• 3-5 hours
• Salbutamol (QDS, PRN)
• Terbutaline (QDS - PRN)

Question 3

LABA

Answer 3

• 12 hours
• Formoterol (BD)
• Salmeterol (BD)

Question 4

Oral B2 agonist tablet

Answer 4

Bambuterol

Question 5

When are LABAs used?

Answer 5

Patients regularly using ICS
Do not initiate in rapidly deteriorating asthma

Question 6

Salmeterol

Answer 6

Long onset + long action
- Not for acute relief or prevention of exercise induced asthma

Question 7

Formoterol

Answer 7

Short onset + Long action
- Can be used as reliever in addition to regular use as a preventer
- Review if using more than once a day

Question 8

Brands

Answer 8

Beclometasone + Formeterol
- Fostair
- DuoResp Spiromax
- Symbicort (18+ years)

Question 9

Side effects

Answer 9

• Hand tremors, tachycardia, hyperglycaemia
• Hypokalaemia
• CV effects

Question 10

Hypokalaemia

Answer 10

Increased risk:
- Concomittant corticosteroids
- B2 agonists
- Theophylline
- Hypoxia in severe asthma

Question 11

CV effects

Answer 11

QT prolongation
Arrythmias
Tachycardia
Arterial hypoxia = MI + hypotension.

Question 12

CV - Caution in…

Answer 12

Hyperthyroidism

Question 13

Label

Answer 13

Must explicitly state dose, frequency and max puffs in 24 hours.