Lytics

Question 1

Tenectaplase (TNK)

Answer 1

Non-antigenic
Fibrin specific
Single dose

Question 2

Reteplase

Answer 2

limited fibrin specificity

2 boluses - needs weight adjustment

Question 3

TPA (alteplace)

Answer 3

moderate fibrin specificity

bolus + administered as drip

Question 4

Streptokinase

Answer 4

HIGHLY ANTIGENIC
NO fibrin specificity
can only use once

Question 5

use of lytics

Answer 5

Sx onset within 12 hours STEMI only
DO NOT USE IN NSTEMI
>120min away from PCI capable center
-transfer to PCI facility after lytic use!
perform angio within 24 hours (not first 2-3 - inc’d bleeding risk)

Question 6

TNK

Answer 6

full dose TNK, ASA, plavix, UFH (if Cr abn)