Malaria Chemo

Question 1

Classification

Answer 1

Tissue schizonticides - dormant
Blood schizonticides
Gametocides

Question 2

Tissue schizonticides

Answer 2

Dormant forms

Question 3

Blood schizonticides

Answer 3

Erythrocytic

Question 4

Gametocides

Answer 4

Kill sexual stage and prevent transmission to mosquitoes

Question 5

Target of antimalarial drugs

Answer 5

Blood schizonticides

Question 6

Suppressive prophylaxis

Answer 6

Blood schizonticides
- 2 weeks before departure and 4 weeks after

Question 7

Terminal prophylaxis

Answer 7

Premaquine (2 weeks) + chloroquine (last 2 weeks)
For vivax and ovale

Question 8

Antimalarial drugs

Answer 8

Aminoquinolones
Artemisinn and derivatives
Primaquine
Dihydro folate reductase inhibitors
Quinine
Mefloquine

Question 9

Aminoquinolines

Answer 9

Chloroquine phosphate
Amodiaquine hydrochloride

Question 10

Aminoquinolones mechanism of action

Answer 10

Inhibits hemozpin formation from heme
Heme lyses cell membrane
Parasites die

Question 11

Clinical cure followed by relapse with

Answer 11

Aminoquinolines except in P. falciparum

Question 12

Radical cure with aminoquinolinones in

Answer 12

P. falciparum only

Question 13

Aminoquinolinones can also be used as prophylaxis to

Answer 13

Suppress merpzoites before RBC infection

Question 14

Aminoquinolinones used in this form of amoebiasis only

Answer 14

Hepatic amoebeasis

Question 15

Uses of aminoquinolinones

Answer 15

MAGI - DMD:
Malaria
Amoebiasis
Giardiasis
Inflammatory
Direct Myocardial Depressant

Question 16

Aminoquinolinones as mild direct Myocardial depressant

Answer 16

Quinidine like effect

Question 17

Small dose for short time - almost no adverse effect

Answer 17

Anti malarial aminoquinolinones

Question 18

Large dose for long time- physiological disturbances and visual disturbances

Answer 18

Anti inflammatory aminoquinolinones

Question 19

Artemisinin and derivatives

Answer 19

Artesunate
Artemether
Dihydroartemisinin

Question 20

Water soluble

Answer 20

Artesunate
Dihydroartemisinin

Question 21

Lipid soluble

Answer 21

Artemether

Question 22

Rapidly metabolised to dihydroartemissin

Answer 22

Artesunate
Artemether
Artemisinin

Question 23

Standard care for ttt of uncomplicated falciarum

Answer 23

Artemisinin

Question 24

Adverse effects of dihydro artemisinin

Answer 24

May be due to underlying malaria rather than medications

Question 25

Primaquine

Answer 25

Primary tissue

Question 26

Primaquine not used as primary tissue schizonticidal

Answer 26

Toxic

Question 27

Radical cure in all stages because anti relapse

Answer 27

Premaqune

Question 28

Met Hb and hemolysis with G6PD deficiency

Answer 28

Primaquine

Question 29

Small dose primaquine

Answer 29

Leukocytosis

Question 30

Large dose primaquine

Answer 30

Leukopenia

Question 31

Dihydrofolate reductase inhibitors

Answer 31

TMP Proguanil Pyrimethamine

Question 32

Biguanides

Answer 32

Proguanil and chlorproguanil (chloroguanide)

Question 33

Pyrimethamine

Answer 33

Daraprim

Question 34

DHFR potentiate by

Answer 34

Sulfonamides - Fansidar

Question 35

Pyrimethamine + sulfadoxine

Answer 35

Fansidar

Question 36

Primaquine not good for falciparum

Answer 36

No target as secondary tissue schizonticides as it doesn't have a dormant liver form

Question 37

Too toxic to be used as chemiprophylaxis with malaria

Answer 37

Primaquine

Question 38

Megaloblastic anaemia side effect treated with

Answer 38

Folinic acid

Question 39

Toxic synergism

Answer 39

Proguanil + promquine

Question 40

Potentiate by sulfonamides but ironically

Answer 40

Resistance between DHFR and sulphonamides

Question 41

Quinine

Answer 41

Suppressive like aminoquinolinones and Erythrocyte schizonticidal

Question 42

Radical cure of chloroquine resistant falciparum

Answer 42

Quinine

Question 43

IV in cerebral malaria

Answer 43

Quinine

Question 44

Reversible on stopping of Quinine

Answer 44

Cinchonoim

Question 45

Leads to black water fever

Answer 45

Quinine

Question 46

Related to quinine

Answer 46

Mefloquine

Question 47

A