MDD Flashcards

(79 cards)

1
Q

Melancholia

A

MDD is first described by Hippocrates as melancholia, resulted from the presence of too much black bile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Kreaplin

A

-group diseases together based on classification of syndromes, not similarity of symptoms
-refeined unitary concept of psychosis
a) manic depression (MDD and BP)
b)dementia Praecox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dementia Praecox

A

-(later known as schiz)
-rapid cognitive disintegration
-disruption in attention, memory, goal directed behaviour
-eventually re-labeled schizophrenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Manic-Depressive Illness

A

-primary mood disturbance
-disruption in affective functioning
-eventually split into multiple mood disorders
-distinguishes radically different forms of functioning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Leonhard

A

-proposes unipolar-bipolar distinction
-either only depression, only mania (unipolar), or both (bipolar)
-discribed as different groups, still true today
-very rare to have only manic episodes, mainly classified as bipolar, if unipolar its depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

DSM2

A

introduced in DSM2 as depressive reaction, or a response to adverse life events

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DSM3

A

MDD was introduced in DSM3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

DSM5 Changes

A

a) addition of disruptive mood dysregulation disorder
b) Dysthymia became persistent depressive disorder
c) premenstural dysphoria disorder
d)bereavement clause was that if 6 months before coming depressed, you couldnt recieve this diagnosis, since been removed bc bereavement and grief and how the person handles it can be a depressive symptom of side effect which must be treated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Diagnosis Criteria

A

-diagnosed when a history of depressive episodes, but no mania
-need five or more symptoms within the same 2-week period
-all must be present simultaneously during that 2 weeks
-person must report experiencing marked distress ir a decrease in fucntioning during these 2-weeks
-at least one must be one of 2 cardinal symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cardinal Symptoms

A
  1. Dysphoric Mood
    2.Anhedonia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dysphoric Mood

A

ppl report feeling really sad, empty, and tearful, most of the day, for more days than not

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anhedoia

A

markedly diminished interest or pleasure in all or almost all activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Symptoms

A

-weight loss/or weight gain
-insomnia or hypersomnia
-psychomotor agitation or retardation
-fatigue or loss of energy
-feelings of worthlessness or excessive or inappropriate guilt
-diminished ability to think/concentrate or indecisiveness
-recurrent thoughts of death, suicidal ideation or attempts
-symptoms must cause serious distress or imapirment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Unipolar vs Bipolar Prevelance

A

-MDD 10-20 x more common than bipolar
-Bipolar: M=F, Unipolar: 2F=1M

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Unipolar vs Bipolar Course

A

-bipolar-earlier onset, more episodes, more pernicious course (ppl have more serious and severe outcomes and they are sick for longer)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Forms of MDD

A

a) Recurrent Depression
b) Melancholia
c) Atypical
d) Chronic Major Depression
e)SAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Recurrent Depression

A

-whether or not ppl have had more than one MDD episode
-attempt to distinguish between heterogeneity of symptoms, allows for a homogenous subgroup
-have more than 3-4 episode typically
-more familial, if a proband has recurrent there is usually more dense of a diagnosis of MDD in family members
-assc with worse outcomes, more sick and sick for longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Melancholia

A

-needed no psychosocial stressor to trigger, thought to be purely biological
-lack of premorbid (before disorder) personaility disturbance (no difference)
-no differences in family history
-bc its supposed to be endogenous, fewer precipitating factors, but evidence i smixed
-symptoms cluster together
-not stable across episodes
-often preceded by a significant stressor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Melancholia Treatment

A

-should respond better to biological interventions (meds)
-do well with ECT but less evidence for anti-depressants (dont do better with pharmacological intervention)
-dont respond to placebos
-do respond to psychotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Melancholia Symptoms

A

-Cardinal one is anhedonia, lack of mood activity
-total despair, intense moreosness or intense emptiness
-mood is consistently worst in the morning, coupled
-marked psychonotor disturbance (agitation or retardation)
-intense weight loss
-excessive or inappropriate guilt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Atypical

A

-15% of depressed patients
-earlier onset
-more comorbidity
-predominantly in women
-intact mood reactivity, sometime too much, react to good things but react to bad things very intensely

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Atypical Symptoms

A

-very intense rejection sensitivity
-hyposomnia, increased appetite, leaden paralysis a feeling of their limbs being made of led and every motion is effortful but others cant see that

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Atypical Treatment

A

-strongly assc/w specific treatment response
-responds preferentially to MAOIs, not tricyclics
-ppl dont usually prescribe MAOIs bc it reacts badly with tiramine, which is in almost all processed foods
-many treated w/SSRIs, less effective, but more convenient and safer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Chronic Major Depression

A

-ppl who have episodes lasting at least 2 years unremittingly
-assc w/higher rates of depression in relatives, not as much as recurrent
-more severe course
-treatments are less effective
-10-25% of ppl will remain sick for this long

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
SAD
-Higher rates of it as you get further from equator -Occurs in winter months -Responds well to light therapy
26
Tripartite Model
How we understand the boundires between anxiety and depression by undestanding similarities and differeces
27
Anxiety & Depression Similarities
negative emotionality, negative affect
28
Depression vs Anxiety
-anhedonia is depression specific -psysiological hypersrousal is anxiety-specific (manifests differently amongst anxiety disorders)
29
Lifetime Prevalence
-16-17% -20-25% for women, 9-12% for men, differs substantially depending on where u look
30
Point Prevelance
6% for women, 3% for men
31
Persistent Depressive Disorder
-3-6% -higher in lower/middle income EA countries than recurrent depression
32
Racial Influence
-Some data showing Black/African-American groups have lower lifetime prevalence (10%) than White Americans (~18%) -Prevalence rates may be higher among Black youth than among White youth -Similarly mixed evidence for prevalence rates in studies looking at First Nations group, Asian-American groups relative to Caucasian-American/White participants -Less likely to have it paradoxically when they receive the diagnosis, so those in minority groups tend to experience it on a longer course and more severe
33
Cultural Expression of Depression
-Frequently more somatic presentation in Asian, Latin American, and North African cultures -Top three symptoms, depressed mood/sadness, fatigue/loss of energy, problems w/sleep – across multiple countries -However, across these countries, the top symptom varies in how frequently endorsed it is -possible that same underlying thing expresses itself differently in different countries
34
Cultural Variation
-western non-indigenous = depressed mood -latin america = fatigue -middle east = depressed -south asia = sleep -southeast asia = issues we hear
35
Persistent Depressive Disorder (Dysthymic Disorder)
very chronic course – even though in terms of symptom presentation it is thought to be less severe, the nature of the length of this disorder can be really impairing
36
Persistent Dperessive Disorder Recovery
-Over 10 year study, 75% recovered -Risk for relapse is high
37
Age of Onset
-Age of onset – usually teens/mid-20s -25% of the time, MDD preceded by low-grade, chronic PDD/depression
38
Episode Duration
-Duration of episodes typically 5-6 months -20% of the time, episodes will >2 years - can set people back in key developmental milestones of adolescence -At least ½ of individuals who have one depressive episode will have at least one more -½ to ⅓ will relapse -4-6 episodes over lifetime is average
39
Predictors of longer episodes
-Personality disorder -Non-mood comorbid disorders
40
Suicide Risk
-Some estimates 15% of people with mood disorders will die by suicide - may be a biased estimate bc it’s taken from mostly inpatient populations -More recent estimates likely: 5-6% inpatients, 2% outpatients -Much higher than general population, risk is substantially elevated
41
Suicide Timing
uicide most common in the 1st 6 months after recovery - thought that it’s most often for people w recurrent depression, in first 6 months after recovery people start to regain energy again, for many of them this is not the first time this sort of cycle has happened, feel like though they have this newfound energy, they know that that depressive state is going to come back again, and so many think that there is this very narrow sort of future for them
42
Proband
person you recruit to study that has the disorder you want to study
43
Familial Influence
-MDD is familial, and bipolar I is familial – see higher rates in family members with these -Suggests that mood disorders broadly may be familial, not perfectly specific because we still see high rates of MDD in those family members
44
Proband: Bipolar 1 Relative Diagnosis:Bipolar 1
3%
45
Proband: Bipolar 1 Relative Diagnosis: Bipolar 2
3%
46
Proband: Bipolar 1 Relative Diagnosis: MDD
10%
47
Proband: MDD Relative Diagnosis: Bipolar 1
1%
48
Proband: MDD Relative Diagnosis:Bipolar 2
1.5%
49
Proband: MDD Relative Diagnosis: MDD
14%
50
Proband: NA Relative Diagnosis:Bipolar 1
0.5%
51
Proband: NA Relative Diagnosis: Bipolar 2
1%
52
Proband: NA Relative Diagnosis: MDD
6%
53
Kendler Twin Study
-For male twins: r = .31 for Mz, .11 for Dz -For female twins: r = .44 for Mz, .16 for Dz -Stronger agreement in female monozygotic twins than female dizygotic twins -Doesn’t tell us anything about shared environmental factors
54
Adoption Studies
-Looked at rates of disorder in biological and adopted families -Also adopted controls -Only biological families had elevated rates of mood disorders -Suggests a genetic component rather than affective environment
55
Freud Early Adversity
early loss of a parent - thought it was THE etiological explanation for MDD, especially if you later faced a second loss
56
Gordon Parker
asks you to reflect on what your experiences of being parented are like based on the 2 dimensions of caregiving
57
2 Dimensions of Caregiving
1) Care, nurturance 2) Overprotection, control
58
Genetic Variables
-Depression in parents, leads to less beneficial parenting, leads to depression in children -OR may be that kids who will become depressed elicit more negative parenting -Passive gene-environment correlation because it doesn’t depend on behavior of children, just environment where kid is growing up -BUT control for parental hx of depression, association still there
59
Caregiving & Depression
-Depressed patients frequently report parents lower in warmth and care - potential mood state bias there, people currently depressed will report that most things are worse than those who are not depressed -Less consistently: higher in overprotection -This interaction poses a heightened risk for depression -Abuse associated with higher rates of depression and chronicity
60
Twin Abuse Study
-1 twin sexually abused, the other not -Rates of depression higher in the abused twin -For a long time people were saying this was basically a genetic disorder, shows that even for genetically identical people, the experiences that you have matter
61
Stress & Depression
-Depressed people more sensitive to the effects of stress -But also generate more stress in their lives -Particularly interpersonal stress
62
Stressful Life Events
-In 6 months prior to onset of MDD, increased rate of stressful life events -20% of women who experienced these events became depressed -75% of depressed women studied had experienced such an event in the 6 months prior -Not seen in non-depressed
63
Stressor Themes
Most powerful stressors related to themes of loss: loss of a loved one, loss of a job, loss of a cherished ideal or goal
64
Dependent Type Stressor
things that aren’t independent of how the person behaves in the world, losing a job, etc. -Dependent seem more strongly predictive of depression
65
Independent Type Stressor
things thought of as fateful stressors, you’re sitting at a red light and are rear ended by a car -Depression associated w/higher number of independent events as well
66
Reward and Positive Reinforcement
-Depression related to a reduction in behaviors that are positively reinforced -Receive less positive reinforcement, mood declines -Become less likely to engage in behaviors that receive positive reinforcement
67
Schemas
-core beliefs, believe that you can have these core beliefs but not have depression until you have a life stressor -dormant, but activated by presence of stressor
68
Becks Cognitive Triad
1. Negative Views abotu the World 2. Negative Views abotu the future 3. negative views about onneself
69
Cognitive Schemas
-not readily accessible by self reports – particularly if they’re not currently in a depressive state -Idea that they are latent and activated specifically in presence of a stressor -Therefore need experimental lab studies
70
Memory Bias
when something bad happens that you expect bad to happen, it goes right into the schema and idea and reinforces this idea that the world is against them, everything is bad for them
71
Attentional Bias
filters info so that people will attend to some things and not others – tendency to focus on the negative info, not positive
72
Self-Referential Encoding Task
-People with depression endorse negative things, more likely to remember the negative words that they endorsed than positive words - affects what they remember about study -Don’t see this in most anxiety disorders, actually, unless comorbid w/depression - seems to demonstrate some specificity to depression
73
Attentional Bias Task (Snake)
-People w/depression will be much faster to find snake than people without depression because attention is immediately and reflexively drawn to negative things -In contrast, they are then really slow to find the mushroom
74
Stroop Task (Colour words)
For someone with depression, they are much slower to say name of color of word bc their attention is so negatively selective that they are slower to do task in presence of negative emotional distracter because they cannot inhibit this tendency to look at emotional distracter
75
Dichotic Listening Task
-for people with depression if they are trying to repeat story that is relatively neutral, and in the other ear they are hearing negative words (death, misery, filth, anger, sorrow, etc.), they have a much harder time repeating what they are hearing from the neutral story bc their attention is so divided -Tend to make more errors and have a harder time remembering content of story they are supposed to listen to
76
Seligman Learned Helplessness Study
-Cage with divider, had floor that was electrified -When exposed to inescapable floor, they learn that nothing that they do affects their environment or makes a meaningful change for them - dogs who learned this helplessness in experience and then would not try to escape, became very lethargic and apathetic
77
Abuse & Depression
kids learn early on that punishment is going to be unpredictable and no matter what they do, nothing will change - example of this learned helplessness - they will still be in trouble even if they do lots of good things so why keep trying?
78
3 Dimensions of Attributions
External vs. internal Global vs. specific Stable vs. unstable
79
Depressive Attributions
Internal, global and stable attribution staples associated with depression