Melancholia
MDD is first described by Hippocrates as melancholia, resulted from the presence of too much black bile
Kreaplin
-group diseases together based on classification of syndromes, not similarity of symptoms
-refeined unitary concept of psychosis
a) manic depression (MDD and BP)
b)dementia Praecox
Dementia Praecox
-(later known as schiz)
-rapid cognitive disintegration
-disruption in attention, memory, goal directed behaviour
-eventually re-labeled schizophrenia
Manic-Depressive Illness
-primary mood disturbance
-disruption in affective functioning
-eventually split into multiple mood disorders
-distinguishes radically different forms of functioning
Leonhard
-proposes unipolar-bipolar distinction
-either only depression, only mania (unipolar), or both (bipolar)
-discribed as different groups, still true today
-very rare to have only manic episodes, mainly classified as bipolar, if unipolar its depression
DSM2
introduced in DSM2 as depressive reaction, or a response to adverse life events
DSM3
MDD was introduced in DSM3
DSM5 Changes
a) addition of disruptive mood dysregulation disorder
b) Dysthymia became persistent depressive disorder
c) premenstural dysphoria disorder
d)bereavement clause was that if 6 months before coming depressed, you couldnt recieve this diagnosis, since been removed bc bereavement and grief and how the person handles it can be a depressive symptom of side effect which must be treated
Diagnosis Criteria
-diagnosed when a history of depressive episodes, but no mania
-need five or more symptoms within the same 2-week period
-all must be present simultaneously during that 2 weeks
-person must report experiencing marked distress ir a decrease in fucntioning during these 2-weeks
-at least one must be one of 2 cardinal symptoms
Cardinal Symptoms
Dysphoric Mood
ppl report feeling really sad, empty, and tearful, most of the day, for more days than not
Anhedoia
markedly diminished interest or pleasure in all or almost all activities
Symptoms
-weight loss/or weight gain
-insomnia or hypersomnia
-psychomotor agitation or retardation
-fatigue or loss of energy
-feelings of worthlessness or excessive or inappropriate guilt
-diminished ability to think/concentrate or indecisiveness
-recurrent thoughts of death, suicidal ideation or attempts
-symptoms must cause serious distress or imapirment
Unipolar vs Bipolar Prevelance
-MDD 10-20 x more common than bipolar
-Bipolar: M=F, Unipolar: 2F=1M
Unipolar vs Bipolar Course
-bipolar-earlier onset, more episodes, more pernicious course (ppl have more serious and severe outcomes and they are sick for longer)
Forms of MDD
a) Recurrent Depression
b) Melancholia
c) Atypical
d) Chronic Major Depression
e)SAD
Recurrent Depression
-whether or not ppl have had more than one MDD episode
-attempt to distinguish between heterogeneity of symptoms, allows for a homogenous subgroup
-have more than 3-4 episode typically
-more familial, if a proband has recurrent there is usually more dense of a diagnosis of MDD in family members
-assc with worse outcomes, more sick and sick for longer
Melancholia
-needed no psychosocial stressor to trigger, thought to be purely biological
-lack of premorbid (before disorder) personaility disturbance (no difference)
-no differences in family history
-bc its supposed to be endogenous, fewer precipitating factors, but evidence i smixed
-symptoms cluster together
-not stable across episodes
-often preceded by a significant stressor
Melancholia Treatment
-should respond better to biological interventions (meds)
-do well with ECT but less evidence for anti-depressants (dont do better with pharmacological intervention)
-dont respond to placebos
-do respond to psychotherapy
Melancholia Symptoms
-Cardinal one is anhedonia, lack of mood activity
-total despair, intense moreosness or intense emptiness
-mood is consistently worst in the morning, coupled
-marked psychonotor disturbance (agitation or retardation)
-intense weight loss
-excessive or inappropriate guilt
Atypical
-15% of depressed patients
-earlier onset
-more comorbidity
-predominantly in women
-intact mood reactivity, sometime too much, react to good things but react to bad things very intensely
Atypical Symptoms
-very intense rejection sensitivity
-hyposomnia, increased appetite, leaden paralysis a feeling of their limbs being made of led and every motion is effortful but others cant see that
Atypical Treatment
-strongly assc/w specific treatment response
-responds preferentially to MAOIs, not tricyclics
-ppl dont usually prescribe MAOIs bc it reacts badly with tiramine, which is in almost all processed foods
-many treated w/SSRIs, less effective, but more convenient and safer
Chronic Major Depression
-ppl who have episodes lasting at least 2 years unremittingly
-assc w/higher rates of depression in relatives, not as much as recurrent
-more severe course
-treatments are less effective
-10-25% of ppl will remain sick for this long