Micro 3 Normal Flora

Question 1

Metagenomics

Answer 1

Genomic study of uncultured microorganisms (shotgun sequencing)

Question 2

Biggest demographic GI flora difference

Answer 2

Infant v. Adult

Question 3

Diverse v Conserved (between subjects)

Answer 3

Species v Metabolic Pathways

Question 4

Gut bacteria roles

Answer 4

Mostly anaerobic, little enteric

Question 5

Gut immunity

Answer 5

Dendritic cells in LP of Peyer’s Patches sense bacteria -> Lymph nodes respond with IgA

Question 6

Epithelial cell secretion against bacterial TLR binding

Answer 6

Reg III gamma, & alpha-defensins

Question 7

Important defense against penetrating bacteria

Answer 7

Th17

Question 8

Reduced normal flora predisposes to what bacterial infection

Answer 8

Clostridia Difficile

Question 9

Normal C. Diff Tx

Answer 9

Vancomycin