mid term prep

Question 1

What are basic numerical values for alpha helix

Answer 1

3.6 residues per turn
5.4 angstrum rise per turn
stbilised by H bond between carbonyl O n and NH n+4

Question 2

Why are glycine + proline helix breakers

Answer 2

Glycine = too flexable for the structure
Protline = cannot form an H-bond with N-termin, to ridged to form appropriate phi bond

Question 3

What is the most common amino acid in beta turns

Answer 3

Proline in the second location -> naturally bends back on itself as side chain binds to amino group forming curve

Question 4

What is a chaperonin

Answer 4

a bin like large chaperone made from two parts GroHS, GrosEL

Question 5

Wat is missfolding of amyloid protein predicted to be associated with

Answer 5

type 2 Diabetes or/and altzhimers