1
Q
increased tone leading to spastic paralysis
A
UMN
2
Q
decreased tone leading to a flacid paralysis
A
LMN
3
Q
is the anterior horn cell only found in the spinal cord?
A
YAAAS
4
Q
which tract crosses in the spinal cord
A
spinothalamic tract
5
Q
tell me about suspended sensory loss
A
when there is something wrong with the anterior white commissure causing a loss of pain and temp. at one or couple of segments in the body
6
Q
Brown sequard syndrome… what is wrong with it?
A
- contralateral pain and temperatures (spinothalamic) - ipsilateral issues with position, vibration (dorsal column pathway) and motor (CST)
7
Q
a motor or sensory level involvement means what?
A
that it is a spinal cord disease because the spinal cord is segmented
8
Q
Sensory levels:
T2 =
T4 =
T10 =
L1 =
L3 =
L5 =
S4-S5 =
A
T2 = clavicle
T4 = nipple line
T10 = umbilicus
L1 = inguinal crease
L3 = medial thigh
L5 = lateral calf
S4-S5 = perianal (“saddle”) area
9
Q
Muscle innervation
Biceps brachii =
Triceps =
Intrinsic hand muscles =
Quadriceps femoris =
Gastrocnemius =
A
Biceps brachii = C5,
Triceps = C7
Intrinsic hand muscles = C8
Quadriceps femoris = L3
Gastrocnemius = S1
10
Q
In spinothalamic tract, sacral fibers are _______, cervical fibers are ______
A
In spinothalamic tract, sacral fibers are lateral, cervical fibers are medial
11
Q
sacral sparing is considered a
A
intrinsic disease
12
Q
syringomyelia
A
suspended sensory loss of pain and temp. leads to weakness and atrophy
13
Q
ALS
A
combined UMN and LMN
14
Q
Tabes Dorsalis
A
Dorsal column
15
Q
Subacute combined degeneration
A
B12 deficiency dorsal column and corticospinal tracts
16
Q
spinocerebellar degneration–> Friedreich’s ataxia
A
- dorsal column - spinocerebellar - CST
17
Q
- spinal muscular atrophies - motor neuron disease -local damage, trauma - ischemia, tumors and infections
A
diseases of motor neurons
18
Q
- axonal degneration - segmental demyelination
A
diseases of peripheral nerves
19
Q
- MG
- Eaton-Lambert syndrome
A
Diseases of NMJ
20
Q
- destructive myopathies
- dystrophies
- polymyositis
- dermatomyositis
A
primary muscle disease
21
Q
mitochondria, glycogen lipids, ion channels, deamin related proteins
A
disorders of intracellular organelles, structural proteins, and enzymes
22
Q
dying back
A
axonal neuropathy
23
Q
Axonal neuropathies
- affects proximal or distal?
- most common causes?
- what do we see on NCV?
A
- distal - toxic and metabolic -decreased amplitudes
24
Q
charcot-marie-tooth type 1 is a
A
herditary,chronic demyelinating neuropathies
25
example of an acute demyelinating neuropathy
guillain-Barre
26
Tell me about Guillain-Barre?
- causes?
- motor \< or \> sensory
- CSF increased or decreases? what about cell count?
- fast or slowed conduction velocity
- tx,
- what is more rapid in recovery? remyelination or axonal regeneration
- autoimmune disorder after a viral or bacterial illness
- motor \> sensory
- CSF increased with normal cell count
- slowed conduction velocity
- tv.: plasma exchange but no steroids
- recovery by remyelination
27
Chronic inflammatory demyelinating neuropathy can be treated by
steroids
28
\_\_\_\_\_ mediated in chemical transmission
ACh
29
Myasthenia Gravis:
- what is happening here?
- what is usually present in terms of symptoms?
- common system affected
- how do we dx?
- 10% of cases have
- tx?
- post-synaptic autoimmune mediated AChR dysfunction
- fatigable weakness is usually present
- most common system affected is ocular
- tensilon test, Ab levels
- 10% have thymomas
- acetylhonesterase inhibitors or immunosuppressive medications
30
lambert- eaton syndrome
- what is it?
- what do we see?
- tell me about the reflexes?
- common paraneoplastic syndrome
- tx?
- autoimmune presynaptic VGCC dysfunction
- slowly progressive proximal weakness with dry mouth
- hyporeflexic
- small cell lung cancer
- prednisone, 3,4diam
31
what are these features suggestive for?
- proximal distribution of weakness
- symmetric muscle weakness
- normal or enlarged muscles
- deep tendon reflex reductions that parallel muscle strength
myopathy
32
these features really do not fit with \_\_\_\_\_\_\_\_
- UMN
- distal weakness
- fasciculations
- tremor
- sensory abnormalities
- fatigable muscle weakness
- early loss of deep tendon relfexes
myopathy
33
what type of muscle enzyme testing we can do to dx myopathies?
creatine kinase
34
dx that involves finger flexors and quads
inclusion body myositis
35
inflammatory myopathies [3]
what do all three show?
what about tx?
- polymyositis
- dermatomyositis
- inclusion body myositis
- elevated CK
- PM and DM respond to immunosuppresive tx. but IBM does not
36
inherited muscle disease largely due to abnormal structural muscle proteins
muscular dystrophies
37
muscular dystrophies diseases?
[3] how are two inherited?
- Duchenne's
- Becker's
- fascioscapulohumeral dystophy
Duchenne's/ Becker's are x-linked but beckers' is less severe as in-frame mutation
38
broad group of inherited disorders of muscle energy metabolism largely presenting with exercise intolerance
metabolic myopathies
39
Cranial nerve determines level:
midbrain =
pons =
medulla =
midbrain = III,IV
pons = V, VI, VII, VIII
medulla = IX, X, XI, XII
40
medial disease localization of the brainstem
CST and medial lemniscus
41
lateral disease localization of the brainstem
Spinothalamic and descending V
42
Medial cranial nerves
- derived from ____ \_\_\_\_\_\_ column
III =
VI =
XII =
Medial cranial nerves:
- derived from somatic motor column
III = midbrain
VI = pons
XII = medulla
43
Lateral cranial nerves - ______ and _____ arch muscles
IX, X, XI =
VII, VIII, V =
Lateral cranial nerves - sensory and branchial arch muscles
IX, X, XI = medulla
VII, VIII, V = pons
44
lateral brainstem syndromes:
Contralateral loss of pain and temperature in body: \_\_\_\_\_\_\_\_\_\_\_
Ipsilateral loss of pain and temperature in face: \_\_\_\_\_\_\_\_\_\_\_\_\_\_
Laterally exiting cranial nerves to branchial arch muscles:
Medulla-
Lower pons-
Upper pons-
Contralateral loss of pain and temperature in body: Spinothalamic tract
Ipsilateral loss of pain and temperature in face: Descending nucleus of V
Laterally exiting cranial nerves to branchial arch muscles:
Medulla- nucleus ambiguous
Lower pons- facial nerve
Upper pons- trigeminal nerve (main sensory, motor)
45
lateral medullary syndrome:
Sensory: [2]
Motor [1]
Other [2]
Sensory: pain and temp
- Ipsilateral face
- Contralateral body Motor
- Ipsilateral palatal weakness (nucleus ambiguus); contralateral uvulal deviation
Other - Ipsilateral
Horner’s syndrome - Ipsilateral dyscoordination/ataxia
46
What is the difference between the lateral pontine syndrome and lateral medullary syndrome?
there is different motor components in the pontine syndrome there is facial weakness due to CN VII affected lateral medullary syndrome affects the nucleus ambiguus so we see palate weakness and contralateral uvula deviation
47
Medial brainstem syndromes:
Contralateral hemiparesis:
involvement of somatic motor nerves exiting medially:
Medulla =
Pons =
Midbrain =
Contralateral loss of position and vibratory sense (which levels of brainstem)
Contralateral hemiparesis:
Corticospinal tract Ipsilateral
involvement of somatic motor nerves exiting medially:
Medulla = XII
Pons = VI
Midbrain = III
Contralateral loss of position and vibratory sense: Medial lemniscus (medulla, lower pons)
48
medial medullary syndrome:
Sensory what type of sensory and where is the deficit?
Motor (be specific in what happens)
Sensory (touch/vibration)
- Contralateral body Motor
- Ipsilateral tongue weakness (CN XII); deviates ipsilaterally
- Contralateral weakness (spares face)
49
medial pontine syndrome and medial medullary are very different.
What happens in medial pontine syndrome?
we know that in medial medullary we are going to have a sensory loss of pain and temp contralateral in the body and ipsilateral in the face. we are also going to see tongue deviated to the week side and contralateral body weakness
For medial pontine syndrome:
- there is loss of touch and vibration in contralateral body
- contralateral weakness and will include face if above facial nucleus ipsilateral weakness
- ipsilateral eye abduction weakness CN VI
50
what the heck is ventral midbrain syndrome? please be specific of what happens with the involved CN
- there will be contralateral weakness of the body and ipsilateral weakness of the face
- ipsilateral CN III.
this leads to a deviated down and out, dilated and unreactive pupil
51
Talk to me about the importance of the cerebellopontine angle:
what CN nerve signs are involved?
early vs late what type of symptoms show up later?
- extrinsic compression of tumors
- begins with CN VIII with vestibular before cochlear
- later involvement of V and VII later when the tumor is bigger it starts to affect:
- middle cerebellar peduncles leading to ataxia
- CST leading to hemiparesis
52
nerves in the cavernous sinus? what is the artery?
CN III, IV, VI, V1 and V2 CN VI closest to the ICA
53
basilar artery occluions involves what motor and sensory tract?
what is variable?
what happens if the reticular system is affected? or not?
- bilateral hemiparesis
- bilateral sensory loss
- variable CN nerve signs
- reticular system:
- if involved: coma
- if spared- "locked- in- syndrome"
54
normal lateral gaze involves
CN 6 and 3
55
conjugate nerve palsy
lesion to CN6
56
internuclear opthalmoplegia
lesion to MLF
57
one and a half syndrome
lesion to both CN 6 and MLF
58
input to the cerebellum all have to pass through the granule cell layer
false all except from inferior olives
59
purkinje cells are found deep to the
cerebellar nuclei
60
how does inferior olive project directly to purkinje cells?
climbing fibers
61
tell me about the inferior cerebellar peduncle. where is it found? why is it important?
found in medulla it receives input from all except cerebral cortex
62
tell me about the middle cerebellar peduncle. where is it found? why is it important?
found in the pons receives only imputs from cerebral cortex (pontocerebellar)
63
tell me about the superior cerebellar peduncle. where is it found? why is it important?
found in the midbrain receives output from cerebellar cortex
64
vestibulocerebellum or also flocculonodular is involved in
balance and oculomotor control
65
spinocerebellum (vermis) involved in
truncal incoordination and leg incoordination
66
neocerebellum (lateral hemispheres) involved in
upper limb ataxia/incoordination
67
Dysdiadochokinesis-
trouble performing rapidly alternating movements
68
tumors, infarct and hemorrhages are unilateral or bilateral?
unilateral
69
cerebellar degenerations are unilateral or bilateral
bilateral
70
what does dopamine do in the direct pathway? what about indirect?
direct- stimulates indirect- inhibits
71
subthalamic nucleus is part of the direct or indirect pathway
indirect
72
where is a loss of dopamine producing cells in substantia nigra located
pars compacta
73
which part of the basal ganglia does HNT affect
caudate nucleus, cortex
74
describe the movement: tremor
oscillatory
75
describe the movement:
myoclonus
jerky
76
describe the movement:
chorea
random
77
describe the movement:
hemiballismus
violent
78
describe the movement:
dystonia
sustained
79
describe the movement:
tics
stereotyped but can be suppressible
80
where is this found?
substantia gelatinosa
all
81
where is this found?
clarke's nucleus
T1-L2
82
where is this found?
intermediolateral column
T1- L3
83
where is this found?
Parasympathetic nucleus
S2-S4
84
where is this found?
Acessory nuleus
medulla- C5
85
What is most medial and lateral in the somatotopic organization of Dorsal column Pathway?
Most medial- sacral most lateral is cervical
86
the spinocerebellar are _____ in the body
ipsilateral
87
centers for regulation of HR and respiration found in
medulla and Pons
88
reticular activating system found in
rostral pons and midbrain
89
what level is this at?
90
what level is this at?
91
Cerebellum blood supply
- posterior inferior cerebellar artery (PICA)
- anterior inferior cerebellar artery (AICA)
- superior cerebellar artery (SCA)
92
Medulla blood supply
- vertebral arteries
- PICA
93
Pons blood supply
- Basilar artery
- AICA
94
Midbrain blood supply
- posterior cerebral artery (PCA)
- Superior Cerebellar artery
Neuroscience
flashcards
Decks in class (35)
# Cards
-
Spinal cord49
-
Spinal cord49
-
neurocytology17
-
localization of lesions in the spinal cord16
-
CNS injury17
-
Peripheral Neuropathies50
-
NMJ diseases16
-
brainstem: medulla59
-
muscle diseases15
-
eye movements9
-
localization of disease in the brainstem32
-
cranial nerve exam25
-
Cerebellum29
-
basal ganglia31
-
midterm review94
-
Thalamus35
-
Hypothalamus29
-
cerebral cortex53
-
Limbic system33
-
Cerebral cortex 220
-
cortical localization28
-
eye physio29
-
visual exam19
-
cellular basis of learning and memory22
-
Stroke26
-
Clinical Stroke27
-
intracranial tumors39
-
Dementia and Alzheimer's30
-
Head trauma15
-
Multiple Sclerosis29
-
epilepsy27
-
exam 2 review158
-
disorders of consciousness and death37
-
embryology of the CNS and congenital malformations44
-
final review pics55
