1
Q
Why Peptidoglycan is a Good Antimicrobial Target?
A
- Unique to prokaryotes so drugs are less toxic to humans
- Found in most bacterial pathogens
- Located outside cytoplasmic membrane, easy for drugs to access
2
Q
β-lactam Antibiotics (Peptidoglycan Cross-linking Inhibitors)
A
- Contain a β-lactam ring that resembles amino acid chain structures in peptidoglycan
- They block enzymes that form cross-links in peptidoglycan
- prevents proper cell wall synthesis
- Ex: Penicillins and Cephems
3
Q
What do β-lactamases do?
A
- Enzymes that hydrolyze the β-lactam ring in antibiotics, inactivating them
- Allows bacteria to resist drugs like penicillin and cephalosporins
4
Q
How do bacteria acquire β-lactamase genes?
A
- Through horizontal gene transfer
- Some E. coli carried penicillinase genes even before clinical penicillin use, showing selective pressure in the environment
5
Q
How can β-lactamase resistance be countered?
A
- Use β-lactam antibiotics with β-lactamase inhibitors
- These block the enzyme and protect the antibiotic
MICR 271
flashcards
Decks in class (36)
# Cards
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Module 1: Section 124
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Module 1: Section 236
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Module 2: Section 1A26
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Module 2: Section 1B54
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Module 2: Section 1C8
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Module 2: Section 1D7
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Module 2: Section 2A16
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Module 2: Section 2B6
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Module 2: Section 2C5
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Module 2: Section 2D12
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Module 3: Section 1A15
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Module 3: Section 1B19
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Module 3: Section 1C16
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Module 3: Section 2A18
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Module 3: Section 2B22
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Module 3: Section 2C31
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Module 3: Section 2D23
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Module 3: Section 2E14
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Module 4: Section 1A24
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Module 4: Section 1B24
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Module 4: Section 2A15
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Module 4: Section 2B14
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Module 4: Section 3A34
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Module 4: Section 3B31
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Module 4: Section 3C21
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Module 5: Section 1A15
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Module 5: Section 1B9
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Module 5: Section 1C14
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Module 5: Section 2A30
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Module 5: Section 2B13
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Module 5: Section 2C32
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Module 6: Section 1A15
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Module 6: Section 1B24
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Module 6: Section 1C14
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Module 6: Section 2A14
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Module 6: Section 2B32
