lactose = __ sugar
milk
lactose is the primary source of __ for all young mammals, including __ __.
carbohydrates, human infants
what classification of carbohydrates is lactose?
disaccharide
what hydrolyzes lactose?
lactase (beta-galactosidase)
when does the ability to digest lactose stop in most populations?
in childhood
after childhood, continued production of lactase is considered what?
a genetically determined trait
if the body cannot digest lactose, what happens to it?
lactose is fermented by bacteria in the colon -> produce gases like CO2, methane and H2
what does lactose attract when it is not digested and what does it cause?
it osmotically attracts fluids into the bowel lumen, causing diarrhea
what is lactase persistence?
genetically programmed continued activity of the lactase enzyme into adulthood
how many copies of LP is required for it to show?
only one copy of the allele because it is a dominant trait
LP phenotype only needs to receive __ copy of the __ __-__ allele from their parents
1, high lactase-activity
LNP phenotype is ___ and receive __ copies of the __ __-__ allele from their parents
homozygous, 2, low lactase-activity
which one is the mutant and ancestral allele from LN and LNP?
LN = mutant allele
LNP = ancestral allele
how did LP arose?
independently
which part of the population is lactose tolerance mostly found?
in population with a long history of consuming milk products
explain the pastoralism -> LP gene-culture coevolution hypothesis
populations were practicing pastoralism
LP mutation occurred
The allele provided a selective advantage and was fixed in the population
explain the LP -> pastoralism gene-culture coevolution hypothesis
LP mutation occurred
The allele became fixed in the population at high frequencies
Pastoralism spread
there is evidence that fermented milk products, like yogurt and cheese, have been produced since around ___ ___.
10 000 BCE
can LNP individuals still tolerate dairy products?
yes, they can tolerate dairy products in which lactose is broken down by LA fermentation process
what is LA fermentation?
LAB ferment lactose -> lactic acid
which mineral is important for skeletal integrity?
calcium
99% of body calcium is in the form of what? where is it found?
calcium hydroxyapatite
found in bones and teeth
what 2 other requirements (aside from calcium) is important for skeletal integrity?
vit D and protein
what is a substitute for vitamin D for skeletal integrity?
sunshine