1
Q
What are nucleic acids linked by?
A
phosphodiester bonds
2
Q
What are the different forms of DNA?
A
A: right handed, 26 A diameter
B: Right handed, 20 A diameter
Z: Left handed, 18 A diameter
3
Q
Which angles are constrained in DNA?
A
glycosidic bond angle and sugar-phosphate backbone angles
4
Q
How can we measure the physical properties of DNA?
A
Melting temperature increases as %GC increases
5
Q
Why does RNA use uracil?
A
use thymine to avoid issues, due to cytosine deaminates
6
Q
Why can RNA not form a B helix?
A
steric clashes
7
Q
Can RNA be stabilized by non-Watson-Crick base pairing?
A
Yes
8
Q
What is the acid-base catalysis in Hammerhead Mechanism?
A
G-12 nitrogen is the base
G-8 hydroxyl group is the acid
BSCI 2520
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