Key causative factors for depression and bipolar disorder (biopsychosocial model)
Biological:
Genetic vulnerability or family history
Neurochemical imbalances (e.g., serotonin, dopamine)
Hormonal changes or medical conditions
Psychological:
Negative thinking patterns
Low self-esteem
Poor coping or problem-solving skills
History of trauma or abuse
Social:
Stressful life events (loss, relationship issues)
Social isolation or lack of support
Socioeconomic hardship
Affect
Observable mood (subjective)
Mood
How the patient feels (objective)
Egocentric
The patient’s thoughts of themselves
Elation
Great happiness or exhilaration
Euthymic
Typical mood range
Dysthymic
Lowered mood that is chronic
Labile
Rapidly changing emotional state
Impulsivity
Behavioural acts based on feelings that lack forethought
Somatisation
Manifestation of psychological distress in the form of physical symptoms
Pressure of speech
Rapid and often loud speech
Anhedonia
Loss of interest in usually pleasurable activities
Psycho-motor retardation
Slowing up of usually fluid physical movements
Depression
Feelings of ‘blue’ to very severe extraordinary sadness, dejection, and inability to take part in life’s activities
What are the DSM-5 diagnostic criteria for Major Depressive Disorder, and what key symptom must be present?
At least five of the following symptoms during the same 2-week period, with at least one being (1) depressed mood or (2) loss of interest or pleasure:
Cyclothymia
Chronic Bipolar Affective Disorder (BPAD) with milder depressive symptoms
Postpartum depression
**Depressive symptoms occurring after 2 weeks post-birth. **
Includes low mood, fatigue, irritability, anxiety, poor concentration, and difficulty bonding with the baby
Grief
What are the stages? (4) S+P, P, D, R
A normal emotional response to loss, progressing through stages:
* Shock and protest – disbelief and emotional numbness
* Preoccupation – intense longing or focus on the deceased
* Disorganisation – difficulty functioning, sadness, withdrawal
* Resolution – gradual acceptance and re-engagement with life
Medical Conditions
Examples:
- Parkinsons disease
- Dementia
- Multiple Sclerosis
- Anaemia
- Brain leisions
- Hypothyroidism
- Thyrotoxicosis
- Cushings syndrome
- Influenza
- Vitamin B12/folate deficiency
Drug reactions
Precipitate Depression: Antihypertensives, corticosteroids, levodopa, digitalis, cytotoxic drugs, antimalarials, sulphonamides, antipsychotics, cholesterol-lowering drugs.
Precipitate Mania: Corticosteroids, antidepressants, levodopa, LSD, cocaine, amphetamines.
DSM-5 Criteria for a manic disorder
A. Persistent and abnormal elated expansive or irritable
B. Increased energy of activity, of 3 or more of the following symptoms:
1 Inflated self-esteem or grandiosity
2 Decreased need for sleep
3 Pressure of speech
4 Flight of ideas or racing thoughts
5 Distractibility
6 Increase in goal directed activity
7 Excessive involvement in pleasurable activity
C. **Mood disturbances causing marked impairment to social or occupational functioning **
D. The episode is not due to substances or medical conditions
Beliefs concerning people who are suicidal
Suicidal individuals are experiencing intense emotional pain or distress.
Suicide can be a cry for help, not always a desire to die.
Feelings of hopelessness, isolation, or entrapment are common.
Support and timely intervention can prevent suicide.
Why do people find it difficult to talk about suicide?
Stigma and fear of judgment.
Shame, guilt, or hopelessness.
Fear of upsetting others or consequences of disclosure.
Lack of skills or words to express thoughts.
Concerns regarding talking about suicide
Fear of saying the wrong thing or making the situation worse.
Anxiety about responsibility if the person acts on suicidal thoughts.
Feeling unprepared or lacking confidence/skills