Morphine

Question 1

What drugs induce histamine release?

Answer 1

• Morphine
• Atricurium
• Mivacurium
• Protamine

Question 2

What is the chemical structure of morphine?

Answer 2

Phenanthrene

Question 3

What is the MOA of morphine?

Answer 3

Opioid agonist

Question 4

What is the post op pain dose of morphine?

Answer 4

5-20mg IV titrated

Question 5

Potential for delayed respiratory depression up to _____hrs after spinal morphine admin

Answer 5

24hrs

Question 6

How does morphine impact PVR?

Answer 6

Decreases PVR with high doses

Question 7

What are the 2 active metabolites of morphine?

Answer 7

• Morphine-3-glucuronide (75-95% inactive)
• Morphine-6-glucuronide (active analgesic)

Question 8

Which patients is half life of morphine prolonged in?

Answer 8

• Elderly
• Liver failure
• Renal failure

Question 9

What is the onset of morphine?

Answer 9

10-20min

Question 10

What is the peak of IV morphine?

Answer 10

15-30 min

Question 11

What is the duration of IV morphine?

Answer 11

4-5hrs

Question 12

What are effects of morphine?

Answer 12

• Analgesia
• Euphoria
• Sedation
• Nausea
• Body warmth
• Heavy extremities
• Dry mouth
• Pruitis

Question 13

How is morphine eliminated?

Answer 13

• Hepatic 1st pass (25%)
• Glucoronic acid conjugation in hepatic and extrahepatic sites

Question 14

Which group of people have increase response to morphine?

Answer 14

Women (slower speed of offset)

Question 15

What is the intraop dose of morphine?

Answer 15

1-10mg

Question 16

What is the postop dose of morphine?

Answer 16

5-20mg