Succinylcholine

Question 1

What is the MOA of succs?

Answer 1

• Depolarizes presynaptic, postsynaptic, and extrajunctional receptors
• Provides desensitization (prolonged contact between the agonist and receptor)
• Attaches to both alpha subunits of nAChR

Question 2

What antagonizes succinylcholine?

Answer 2

Non depolarizers

Question 3

What augments succinylcholine?

Answer 3

Acetylcholinesterase

Question 4

Why is succs the gold standard for difficult airways/RSI?

Answer 4

Provides excellent intubating conditions within 60 seconds

Question 5

Which patients would you not want to use succinylcholine?

Answer 5

• Burns
• Paralyzed patients
• Renal failure with increased K+
  can increase K+ 0.5

Question 6

What dose of succinylcholine can be used to break laryngospasm?

Answer 6

10-20mg IV

Question 7

Why is there muscle twitching seen when using succinylcholine?

Answer 7

Med causes depolarization and creates action potential that causes small contraction

Question 8

What category of drug is succinylcholine?

Answer 8

nACh-receptor agonist

Question 9

How does succinylcholine impact the eyes?

Answer 9

More calcium coming in causes more contractions and can increase intraocular pressure
risk with giving too much and causing pressure on optic nerve leading to blindness

Question 10

What is the trade name of succinylcholine?

Answer 10

Anectine

Question 11

What drug interaction dose ketamine have with succinylcholine?

Answer 11

Prolongs succs (inhibits plasma cholinesterases?)

Question 12

How is succinylcholine broken down?

Answer 12

Hydrolyzed by Butyrylcholinesterase (plasm cholinesterase)

Question 13

What are side effects of Succinylcholine?

Answer 13

• Cardiac dusrhythmias
• Hyperkalemia
• Myalgia
• Myoglobinuria
• Increased gastric pressure
• Increased IOP
• Increased ICP
• Massester spasm