MR

Question 1

Advantages of MR

Answer 1

Better therapeutic outcome
Decrease toxicity 
Wide therapeutic window
Less dosage problems (better patient compliance)
Decrease total drug exposure

Question 2

Disadvantages of MR

Answer 2

Danger of tablet crushing 
Danger of drug dumping 
Development cost
GI resistance 
Loss of dosing frequency/prolonged side effects if wrong dose is given

Question 3

Types of MR delivery forms

Answer 3

Delayed release 
GI resistant 
Extended release
Oral gastro resistant formulations 
Oral extended release formulations

Question 4

Osmosis controlled

Answer 4

Osmosis pressure is used to pump out a drug at a constant rate from the delivery system inside the matrix. through a delivery orifice

• zero order
• coating technology is cheap
• wide range of compatible drugs
• size of hole and drilling is expensive.

Question 5

MR mechanism for triggered release (2)

Answer 5

pH control

Microbial triggered release

Question 6

Osmosis controlled

Answer 6

Osmosis pressure is used to pump out a drug at a constant rate from the delivery system inside the matrix. through a delivery orifice

• zero order
• coating technology is cheap
• wide range of compatible drugs
• size of hole and drilling is expensive.