1
Q
Advantages of direct compression
A
- Increase stability eliminates heat and moisture
- Efficient and economical
- Fewer exceipents
- Batch to batch variable
- Increase dissolution rate of particles
- No ageing effect
2
Q
Disadvantage of direct compression
A
- Powder flowability and compressibility
- Not suitable for high dose drug
- Expensive equipment
- Problematic compression process.
3
Q
Three types of fillers
A
- Lactose
- Cellulose
- Starch and derivatives
4
Q
Lactose
A
- Advantages: Dissolves readily in water/ nice taste/ non hygroscopic/ non reactive/ good compatibility
- Disadvantages: Lactose intollerant patients
5
Q
Celluslose
A
-Advanatges: Bicompactible/ inert/ high dilution potential
PPM 2
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