Multiple Sclerosis

Question 1

True or false: The cortex is spared in Multiple Sclerosis

Answer 1

False

Question 2

5 Key symptoms of MS

Answer 2

1. Blurred vision
2. Internuclear Opthalmoplegia
3. Weakness/Myelitis
4. Facial Pain (Trigeminal Neuralgia)
5. Fatigue

Question 3

ADEM clears up in about 6 months. What is ADEM and what causes it to mimic MS?

Answer 3

• Acute Disseminated Encephalomyelitis

- Virus or Vaccine induction

Question 4

Neuromyelitis Optica Spectrum Disorders (NMOSD) mimic MS and are caused by _______ defects. Optic nerves and spinal cord are strongly affected.

Answer 4

Aquaporin-4

Question 5

4 main treatments to manage Acute MS relapses

Answer 5

1. IV steroids
2. ACTH
3. Plasmapheresis
4. IV Ig

Question 6

Why would targeting NADPH enzymes, S1P receptors on T-cells, CD20 on B-cells, or VCAM-1 Adhesion molecules be helpful in MS?

Answer 6

Because MS has a strong immunological component