NE

Question 1

Phenelzine

Tranylcypromine

Answer 1

1. MAO inhibitor type A
2. Depression
3. Increases NE, 5HT, and tyramine

Question 2

Selegiline

Answer 2

1. MAO inhibitor type B
2. Parkinson’s disease
3. Increases Dopamine

Question 3

Methyl-p-tyrosine

Answer 3

1.

2.

3. Interference with NE synthesis

Question 4

Amphetamine

Answer 4

1. Indirect acting sympathomimetic
2. ADHD, Weight loss, Narcolepsy
3. Displacement of NE from the Mobile Pool. CNS release of both NE and DA

Question 5

Cocaine

Answer 5

1. Indirect acting sympathomimetic
2. Local anesthetic
3. Block reuptake of NE, DA, and 5HT. Block Na++ channels

Question 6

Reserpine

Answer 6

1.

2. Hypertension
3. Inhibits NE granule uptake –> Reduce NE levels

Question 7

Guanethidine

Answer 7

1.

2. Hypertension
3. Blocks the release of NE from granules

Question 8

Ephedrine

Answer 8

1. Indirect acting sympathomimetic
2. decongestant
3. Displacement of NE from the Mobile Pool

Question 9

Tricyclic antidepressants

Answer 9

1.

2.

3. Blocks Reuptake of NE