NAPLEX :,) > non sterile compounding > Flashcards

non sterile compounding Flashcards

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1
Q

wash equipment and utensils with

A

purified water

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2
Q

store off the floor

A

ingredients, equipment, containers

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3
Q

measuring volumes that are smaller than ___ of graduate’s capacity can cause measuring error

A

20%

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4
Q

syringes

A

most accurate for measuring small volumes, especially useful for measuring thick (viscous) liquids

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5
Q

Mohr pipette

A

graduated (has lines)

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6
Q

glass mortars

A

liquids and compounds that are oily, can stain

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7
Q

wedgewood mortar (rough surface)

A

dry crystals, hard powders

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8
Q

porcelain (smooth surface)

A

blending powders, pulverizing gummy consistencies

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9
Q

volumetric pipette

A

draws up set volume only

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10
Q

electric mixing equipment

A

ointment mills, homogenizers, grinder

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11
Q

gelatin

A

pork derived

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12
Q

hypromellose

A

plant derived

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13
Q

surfactants

A

lower surface tension between 2 ingredients to make more miscible

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14
Q

levigation

A

grind particles (make smaller) with small amount of liquid (wetting agent)

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15
Q

mineral oil

A

levigating agent for lipophilic (oil soluble) compound

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16
Q

glycerin or propylene glycol

A

levigating agent for aqueous (water soluble compound)

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17
Q

suspending agent (or dispersing agent)

A

keep solid particles from settling (must be shaken)

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18
Q

Ora-Plus

A

suspending agent with bland taste

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19
Q

Ora-Sweet

A

suspending agent with flavor

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20
Q

foaming agent (anti-foaming)

A

simethicone

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21
Q

aspartame (contains phenylalanine)

A

granules, ODTs, chewable tablets

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22
Q

emulsion

A

2 or more liquids that are immiscible

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23
Q

emulsifier

A

emulsifying agent keep liquid droplets disperse throughout

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24
Q

HLB

A

hydrophilic lipophilic balance

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25
HLB <10 (Span 65)
more lipid soluble (use for water in oil emulsion)
26
HLB >10 (PEG 400, Tween 85)
water water soluble (use for oil in water emulsion)
27
binder (starch paste)
allows contents of tablets to stick together
28
diluent/filler for capsules or tabs
lactose, starches, cellulose, calcium salts
29
diluent/filler for topicals
petrolatum
30
disintegrants
facilitate breakup of tabs after PO administration; must be dissolved to be absorbed in SI
31
disintegrants
starches, cellulose, alginic acid
32
non caloric sweetener
aspartame, sucralose
33
sweeteners
glycerin, dextrose, mannitol, sorbitol, xylitol, stevia
34
lubricant (anti adherent)
improves powder flowability
35
lubricant
magnesium stearate
36
don't use preservatives in
neonates (0-28 days)
37
adsorbents
keep powders dry
38
adsorbents
magnesium oxide/carbonate, kaolin
39
coatings
prevent degradation, mask unpalatable taste
40
enteric coating
prevent drug degradation in stomach for drugs destroyed by stomach acid
41
purification (remove chemicals/contaminants)
distillation, deionization, reverse osmosis
42
distilled water
used for reconstitution (non sterile compounding)
43
potable water
tap water
44
alcohol
high miscibility with water
45
IPA 70%
preferred disinfectant in sterile compounding
46
glycols
water-miscible, water-soluble
47
oinment
extremely dry and thick skin
48
cream
normal to dry skin
49
lotion
have the most water; oily skin
50
occlusive ointments
form protective barrier to prevent loss of water from top of skin (petrolatum, theobroma, waxes)
51
ointments
0-20% water
52
oleaginous ointments
contains no water (Vaseline Petrolatum Jelly)
53
creams
20-50% water
54
lotions
contain the most water; alcohol added to solubilize ingredients (alcohol is highly miscible with water)
55
gels
liquid in refrigerator, gel in room temperature
56
avoid in children
alcohol
57
avoid in PKU
aspartame (contains phenylalanine)
58
gluten
starch filler
59
gluten contained in
wheat, barely, rye
60
avoid in celiac disease
gluten
61
starch from non gluten sources
corn, potato, tapoica
62
avoid sucrose in (table sugar)
diabetes
63
avoid xylitol in
dogs, human with GI upset from xylitol
64
neutralize static charge
sodium lauryl sulfate
65
communition
reduce particle size by grinding, crushing, milling, vibrating
66
3 methods of communition (make powder particle smaller)
trituration, levigation + spatulation, pulverization
67
trituration
just means mix thoroughly / make homogenous
68
spatulation
instead of in mortar and pestle, performing levigating (adding wetting agent) on ointment slab
69
pulverization
used for crystalline powders
70
pulverization
mix until solvent evaporates, and when powder recrystallizes, the particles become finer
71
melting point order (high to low)
line up ingredients from highest to lowest melting temperature and melt in that order
72
eutectic mixtures
combo of ingredients will melt at lower temperature
73
sedimentation
solid settling on bottom of container
74
continental (dry gum) method (emulsion)
levigate gum with oil, add water all at once, triturate until you hear cracking sounds and mixture is creamy white, homogenize
74
larger surface area
smaller particles (inc dissolution rate)
75
english (wet gum) method (emulsion)
triturate gum with water to form mucilage (thick, sticky), add oil slowly
76
molded tablets
compounding
77
compressed tablets
manufacturing
78
glycerol or sorbitol
used as plasticizer to make capsules less brittle and more flexible
79
hard lozenge
syrup, sucrose
80
soft lozenge
PEG
81
chewable lozenge
glycerin, gelatin
82
fusion method
ointments that require heat to mix components well
83
fusion molding (suppositories)
heat base, add ingredients, pour mixture in room temp mold
84
periodic testing of compounding preparation
QA
85
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