OECD Guidelines

Question 1

Based on current OECD Guidelines, what tester strains of Salmonella typhimurium that revert at GC base pairs should be used in the Ames Assay?
A. TA 1536, TA 110, TA 1518, TA 85
B. TA 1548, TA 102, TA 1505, TA 92
C. TA 1535, TA 100, TA 1538, TA 98
D. TA 1540, TA 200, TA 104, TA 80

Answer 1

C. TA 1535, TA 100, TA 1538, TA 98

Explanation and Reference:
The correct answer lists the recommended tester strains in which reversion by GC base-pair substitutions and frameshift mutations in several DNA sequence contexts can be detected and distinguished. The other answers give wrong numbers for some of the strains. C&D 9th, pp. 520-521