STEP One > Oncogenes > Flashcards

Oncogenes Flashcards

(12 cards)

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1
Q

ALK

A

Receptor tyrosine kinase

Lung adenocarcinoma

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2
Q

BCR-ABL

A

Tyrosine kinase

CML, ALL

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3
Q

BCL-2

A 
Antiapoptotic molecule (inhibits apoptosis) 
Follicular and diffuse large B cell lymphoma
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4
Q

BRAF

A

Serine/threonine kinase

Melanoma, non-Hodgkin Lymphoma

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5
Q

c-KIT

A

Cytokine receptor

Gastrointestinal stromal tumor (GIST)

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6
Q

c-MYC

A

Transcription factor

Burkitt lyphoma

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7
Q

HER2/neu (c-erbB2)

A

Tyrosine kinase/growth factor receptor

Breast and Gastric carcinoma

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8
Q

JAK2

A

Tyrosine kinase

Chronic myeloproliferative disorders

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9
Q

KRAS

A

GTPase

Colon cancer, lung cancer, pancreatic caner

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10
Q

MYCL1

A

Transcription factor

Lung tumor

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11
Q

MYCN

A

Transcription factor

Neuroblastoma

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12
Q

RET

A

Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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STEP One
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