Oncology Flashcards

(22 cards)

1
Q

Deciding a Folate Product with Methotrexate:
Autoimmune Diseases

A

Methotrexate given weekly
Folic acid 1-5mg daily
Leucovorin not used unless unresponsive to folic acid

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2
Q

Deciding a Folate Product with Methotrexate:
Oncologic Diseases

A

Methotrexate doses are higher
Leucovorin required for doses >/=500 mg/m^2
Folic acid is not effective

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3
Q

Chemoman:
Neurotoxicity

A

Carmustine

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4
Q

Chemoman:
Cisplatin

A

Ototoxicity
High Emetogenicity
Nephrotoxicity

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5
Q

Chemoman:
Mucositis

A

Methotrexate
Fluorouracil
Capecitabine

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6
Q

Chemoman:
Pulmonary Toxicity

A

Bleomycin
Busulfan
Carmustine

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7
Q

Chemoman:
Doxorubicin and other Anthracyclines

A

Cardiotoxicity

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8
Q

Chemoman:
Ifosfamide and Cyclophosphamide

A

Hemorrhagic cystitis

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9
Q

Chemoman:
Irinotecan

A

Diarrhea

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10
Q

Chemoman:
Platinum based compounds, Vinca Alkaloids, Taxanes

A

Peripheral neuropathy

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11
Q

Chemoman:
Bone Marrow Suppression

A

Most EXCEPT Bleomycin, Pegaspargase, Vincristine

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12
Q

Cisplatin Nephrotoxicity Prevention

A

Amifostine
Limit dose per cycle to </=100mg/m^2

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13
Q

Methotrexate Mucositis Prevention

A

Leucovorin

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14
Q

Bleomycin Pulmonary Toxicity Prevention

A

Limit lifetime dose to 400 units

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15
Q

Doxorubicin Cardiotoxicity Prevention

A

Dexrazoxane
Limit lifetime dose to 450-550 mg/m^2

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16
Q

Hemorrhagic Cystitis Prevention

17
Q

Irinotecan Diarrhea Prevention

18
Q

Oxaliplatin Peripheral Neuropathy Prevention

A

Avoid cold exposure

19
Q

Vincristine Peripheral Neuropathy Prevention

A

Limit single doses to 2mg

20
Q

Myelosuppression Summary:
White Blood Cells

A

Neutropenia, fever, infection
Prevention: G-CSF in high risk
Treatment: Antibiotics if febrile

21
Q

Myelosuppression Summary:
Platelets

A

Thrombocytopenia, bleeding
Treatment: platelet transfusion

22
Q

Myelosuppression Summary:
Red Blood Cells

A

Anemia, weakness, fatigue
Treatment: RBC transfusion if symptomatic, ESA in select patients