OpenQuestions

Question 1

Rash after antibiotic for IM

Answer 1

Unknown?

Question 2

Pathogenesis of Leser-Trelat sign, acanthosis nigricans, PAN

Answer 2

In gastric cancer

Question 3

Cancer associated with: membranous nephropathy, MAHA, PAN

Answer 3

How does gastric cancer drive these autoimmune conditions?

Question 4

Why is AFP elevated in HCC?

Answer 4

And also in neural tube defects

Question 5

Are temporal patterns easy way to crack a differential?

Answer 5

Examples: PSGN vs IgA nephropathy, BPPV,

Question 6

Diseases with non-specific symptoms

Answer 6

1. Fatigue, nausea, malaise, anorexia: uremia. Easily found by BMP.
2. he major clinical manifestations of iron accumulation in advanced HH include liver disease, weakness and lethargy, skin pigmentation, diabetes mellitus, arthropathy, impotence in males, and cardiac enlargement with or without heart failure or conduction defects: easily spotted by ferritin, transferrin
   3.

Question 7

List of diseases easily diagnosed by readily avaliable numbers

Answer 7

1. PSGN
2. BNP for CHF
3. Prolactin for infxn
4. D-dimer?

Question 8

What is the relationship between “rheumatological” disorders, autoimmune disorders and allergic disorders? For example: where does IgG4 related disorders fall?

Answer 8

1. We should study Crohn’s and RA under the same rubric – should we?
2. Anything that you treat with steroids: should they be treated with rituximab?

Question 9

MABs and PMFL: how can a MAB cause PMFL

Answer 9

Natalizumab — Natalizumab is a humanized monoclonal antibody directed against alpha-4 integrin. It acts by blocking leukocyte migration to sites of inflammation. The use of natalizumab has been limited by its association with progressive multifocal leukoencephalopathy.